Phenotypes associated with this allele

• Allele Symbol: Gata2^tm1Msal
• Allele Name: targeted mutation 1, Marjo Salminen
• Allele ID: MGI:4818492
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	En1^tm2(cre)Wrst/En1^+ Gata2^tm1Msal/Gata2^tm1Msal	involves: 129S1/Sv * 129X1/SvJ	MGI:4818570

Genotype
MGI:4818570

cn1

• Allelic Composition: En1^tm2(cre)Wrst/En1⁺; Gata2^tm1Msal/Gata2^tm1Msal
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:143527 )

N • mice exhibit normal midbrain morphology and neuronal precursor proliferation, survival, patterning, and cell cycle exit

abnormal neuron differentiation ( J:143527 )

• GABAergic precursor cells adopt marker expression similar to precursor cells in glutamatergic regions unlike in wild-type mice

abnormal GABAergic neuron morphology ( J:143527 )

• mice lack GABAergic neuron precursors at the dorsoventral and anteroposterior levels of the midbrain unlike in wild-type mice

• however, GABAergic neurons form in the rhombomere 1 and ventral dopaminergic nuclei

abnormal serotonergic neuron morphology ( J:143527 )

• rhombomere 1 lack serotonergic neurons unlike in wild-type mice

cellular

abnormal neuron differentiation ( J:143527 )

• GABAergic precursor cells adopt marker expression similar to precursor cells in glutamatergic regions unlike in wild-type mice