About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Chek1tm2.1Sje
targeted mutation 2.1, Stephen J Elledge
MGI:4818574
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Chek1tm2.1Sje/Chek1+
Trp53tm1Brn/Trp53tm1Brn
Tg(MMTV-cre)#Mam/0 		involves: 129P2/OlaHsd * FVB MGI:4818610
cn2
 		Chek1tm2.1Sje/Chek1tm2.1Sje
Trp53tm1Brn/Trp53tm1Brn
Tg(MMTV-cre)#Mam/0 		involves: 129P2/OlaHsd * FVB MGI:4818615
cn3
 		Chek1tm2.1Sje/Chek1tm2.1Sje
Trp53tm1Brn/Trp53+
Tg(MMTV-cre)#Mam/0 		involves: 129P2/OlaHsd * FVB MGI:4818618
cn4
 		Chek1tm2.1Sje/Chek1+
Trp53tm1Brn/Trp53+
Tg(MMTV-cre)#Mam/0 		involves: 129P2/OlaHsd * FVB MGI:4818619
cn5
 		Chek1tm2.1Sje/Chek1+
Tg(MMTV-cre)#Mam/0 		involves: FVB MGI:4818608
cn6
 		Chek1tm2.1Sje/Chek1tm2.1Sje
Tg(MMTV-cre)#Mam/0 		involves: FVB MGI:4818609


Genotype
MGI:4818610
cn1
Allelic
Composition		 Chek1tm2.1Sje/Chek1+
Trp53tm1Brn/Trp53tm1Brn
Tg(MMTV-cre)#Mam/0
Genetic
Background		 involves: 129P2/OlaHsd * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chek1tm2.1Sje mutation (0 available); any Chek1 mutation (41 available)
Tg(MMTV-cre)#Mam mutation (0 available)
Trp53tm1Brn mutation (18 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary gland tumor incidence ( J:162126 )
• 7 of 11 mice develop mammary gland tumors with a latency of 9 months unlike wild-type mice
decreased tumor incidence ( J:162126 )
• mice develop fewer tumors than in Trp53tm1Brn Tg(MMTV-cre)Mam homozygotes

endocrine/exocrine glands
abnormal mammary gland alveolus morphology ( J:162126 )
• at 12 months fewer alveoli are found within the mammary glands compared to in wild-type mice
increased mammary gland tumor incidence ( J:162126 )
• 7 of 11 mice develop mammary gland tumors with a latency of 9 months unlike wild-type mice
mammary gland hyperplasia ( J:162126 )
• mammary glands exhibit multifocal hyperplasia unlike in wild-type mice that are more uniform than in Chek1tm2.1Sje Trp53tm1Brn Tg(MMTV-cre)Mam heterozygotes

integument
abnormal mammary gland alveolus morphology ( J:162126 )
• at 12 months fewer alveoli are found within the mammary glands compared to in wild-type mice
increased mammary gland tumor incidence ( J:162126 )
• 7 of 11 mice develop mammary gland tumors with a latency of 9 months unlike wild-type mice
mammary gland hyperplasia ( J:162126 )
• mammary glands exhibit multifocal hyperplasia unlike in wild-type mice that are more uniform than in Chek1tm2.1Sje Trp53tm1Brn Tg(MMTV-cre)Mam heterozygotes




Genotype
MGI:4818615
cn2
Allelic
Composition		 Chek1tm2.1Sje/Chek1tm2.1Sje
Trp53tm1Brn/Trp53tm1Brn
Tg(MMTV-cre)#Mam/0
Genetic
Background		 involves: 129P2/OlaHsd * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chek1tm2.1Sje mutation (0 available); any Chek1 mutation (41 available)
Tg(MMTV-cre)#Mam mutation (0 available)
Trp53tm1Brn mutation (18 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:162126 )
N
• mammary glands do not exhibit hyperplastic foci

neoplasm
abnormal tumor morphology ( J:162126 )
• tumors are more complex than in Trp53tm1Brn Tg(MMTV-cre)Mam homozygotes
decreased tumor incidence ( J:162126 )
• mice develop fewer tumors than in Trp53tm1Brn Tg(MMTV-cre)Mam homozygotes

endocrine/exocrine glands
abnormal mammary gland alveolus morphology ( J:162126 )
• at 12 months fewer alveoli are found within the mammary glands compared to in wild-type mice

integument
abnormal mammary gland alveolus morphology ( J:162126 )
• at 12 months fewer alveoli are found within the mammary glands compared to in wild-type mice




Genotype
MGI:4818618
cn3
Allelic
Composition		 Chek1tm2.1Sje/Chek1tm2.1Sje
Trp53tm1Brn/Trp53+
Tg(MMTV-cre)#Mam/0
Genetic
Background		 involves: 129P2/OlaHsd * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chek1tm2.1Sje mutation (0 available); any Chek1 mutation (41 available)
Tg(MMTV-cre)#Mam mutation (0 available)
Trp53tm1Brn mutation (18 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary gland tumor incidence ( J:162126 )
• 3 of 21 mice develop mammary gland tumors with a latency of 21 months unlike wild-type mice

endocrine/exocrine glands
abnormal mammary gland alveolus morphology ( J:162126 )
• at 12 months fewer alveoli are found within the mammary glands compared to in wild-type mice
increased mammary gland tumor incidence ( J:162126 )
• 3 of 21 mice develop mammary gland tumors with a latency of 21 months unlike wild-type mice

integument
abnormal mammary gland alveolus morphology ( J:162126 )
• at 12 months fewer alveoli are found within the mammary glands compared to in wild-type mice
increased mammary gland tumor incidence ( J:162126 )
• 3 of 21 mice develop mammary gland tumors with a latency of 21 months unlike wild-type mice




Genotype
MGI:4818619
cn4
Allelic
Composition		 Chek1tm2.1Sje/Chek1+
Trp53tm1Brn/Trp53+
Tg(MMTV-cre)#Mam/0
Genetic
Background		 involves: 129P2/OlaHsd * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chek1tm2.1Sje mutation (0 available); any Chek1 mutation (41 available)
Tg(MMTV-cre)#Mam mutation (0 available)
Trp53tm1Brn mutation (18 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
abnormal tumor vascularization ( J:162126 )
• extensive with patches of reduced angiogenesis
increased mammary gland tumor incidence ( J:162126 )
• 20 of 33 mice develop mammary gland tumors with a median latency of 10.5 months unlike wild-type mice
abnormal tumor morphology ( J:162126 )
• tumors are more complex than in Trp53tm1Brn Tg(MMTV-cre)Mam homozygotes
• tumors exhibit aneuploidy and chromosomal aberrations

cellular
aneuploidy ( J:162126 )
• in tumors

cardiovascular system
abnormal tumor vascularization ( J:162126 )
• extensive with patches of reduced angiogenesis

endocrine/exocrine glands
abnormal branching of the mammary ductal tree ( J:162126 )
• at 12 months, mammary glands exhibit increased branching morphogenesis and hyperplastic foci compared to in wild-type mice
abnormal mammary gland alveolus morphology ( J:162126 )
• at 12 months fewer alveoli are found within the mammary glands compared to in wild-type mice
increased mammary gland tumor incidence ( J:162126 )
• 20 of 33 mice develop mammary gland tumors with a median latency of 10.5 months unlike wild-type mice
mammary gland hyperplasia ( J:162126 )
• starting at 12 months, mammary glands exhibit hyperplastic and non-invasive focal lesions unlike wild-type mice

integument
abnormal branching of the mammary ductal tree ( J:162126 )
• at 12 months, mammary glands exhibit increased branching morphogenesis and hyperplastic foci compared to in wild-type mice
abnormal mammary gland alveolus morphology ( J:162126 )
• at 12 months fewer alveoli are found within the mammary glands compared to in wild-type mice
increased mammary gland tumor incidence ( J:162126 )
• 20 of 33 mice develop mammary gland tumors with a median latency of 10.5 months unlike wild-type mice
mammary gland hyperplasia ( J:162126 )
• starting at 12 months, mammary glands exhibit hyperplastic and non-invasive focal lesions unlike wild-type mice




Genotype
MGI:4818608
cn5
Allelic
Composition		 Chek1tm2.1Sje/Chek1+
Tg(MMTV-cre)#Mam/0
Genetic
Background		 involves: FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chek1tm2.1Sje mutation (0 available); any Chek1 mutation (41 available)
Tg(MMTV-cre)#Mam mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:162126 )
N
• mice do not develop mammary gland tumors

endocrine/exocrine glands
abnormal mammary gland morphology ( J:162126 )
• at 2 to 12 months, mammary glands are less dense than in wild-type mice
abnormal mammary gland alveolus morphology ( J:162126 )
• at 12 months fewer alveoli are found within the mammary glands compared to in wild-type mice

integument
abnormal mammary gland morphology ( J:162126 )
• at 2 to 12 months, mammary glands are less dense than in wild-type mice
abnormal mammary gland alveolus morphology ( J:162126 )
• at 12 months fewer alveoli are found within the mammary glands compared to in wild-type mice




Genotype
MGI:4818609
cn6
Allelic
Composition		 Chek1tm2.1Sje/Chek1tm2.1Sje
Tg(MMTV-cre)#Mam/0
Genetic
Background		 involves: FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chek1tm2.1Sje mutation (0 available); any Chek1 mutation (41 available)
Tg(MMTV-cre)#Mam mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:162126 )
N
• mice do not develop mammary gland tumors

endocrine/exocrine glands
abnormal mammary gland morphology ( J:162126 )
• at 2 to 12 months, mammary glands are less dense than in wild-type mice
abnormal mammary gland alveolus morphology ( J:162126 )
• at 12 months fewer alveoli are found within the mammary glands compared to in wild-type mice

integument
abnormal mammary gland morphology ( J:162126 )
• at 2 to 12 months, mammary glands are less dense than in wild-type mice
abnormal mammary gland alveolus morphology ( J:162126 )
• at 12 months fewer alveoli are found within the mammary glands compared to in wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory