Phenotypes associated with this allele

• Allele Symbol: Mrtfb^tm2.1Eno
• Allele Name: targeted mutation 2.1, Eric N Olson
• Allele ID: MGI:4818683
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Mrtfa^tm1Eno/Mrtfa^tm1Eno Mrtfb^tm2.1Eno/Mrtfb^tm2.1Eno Tg(GFAP-cre)25Mes/0	involves: 129 * 129S/SvEv * C57BL/6 * FVB/N	MGI:4818692
cn2	Mrtfb^tm2.1Eno/Mrtfb^tm2.1Eno Tg(GFAP-cre)25Mes/0	involves: 129S/SvEv * C57BL/6 * FVB/N	MGI:4818691

Genotype
MGI:4818692

cn1

• Allelic Composition: Mrtfa^tm1Eno/Mrtfa^tm1Eno; Mrtfb^tm2.1Eno/Mrtfb^tm2.1Eno; Tg(GFAP-cre)25Mes/0
• Genetic Background: involves: 129 * 129S/SvEv * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:161853 )

• mice die between P16 and P21

nervous system

increased neuron apoptosis ( J:161853 )

• in the striatum

abnormal neuron differentiation ( J:161853 )

• neurons exhibit defective neurite outgrowth compared with wild-type neurons

abnormal neuronal migration ( J:161853 )

• neurons fail to migrate along the rostral migratory stream unlike in wild-type mice

absent corpus callosum ( J:161853 )

absent anterior commissure ( J:161853 )

decreased striatum size ( J:161853 )

• mice exhibit a smaller striatum than wild-type mice

abnormal hippocampus morphology ( J:161853 )

• the hippocampus is compressed unlike in wild-type mice

abnormal dentate gyrus morphology ( J:161853 )

abnormal hippocampus pyramidal cell layer ( J:161853 )

• poorly defined

abnormal hippocampus neuron morphology ( J:161853 )

• hippocampal neuronal projections are decreased compared to in wild-type mice

abnormal olfactory bulb morphology ( J:161853 )

• olfactory bulbs contain fewer neurons than in wild-type mice

abnormal rostral migratory stream morphology ( J:161853 )

• neurons fail to migrate along the rostral migratory stream unlike in wild-type mice

abnormal postnatal subventricular zone morphology ( J:161853 )

• mice exhibit an expansion of the subventricular zone compared with wild-type mice

• however, expansion is not do to increased cell proliferation

cellular

increased neuron apoptosis ( J:161853 )

• in the striatum

abnormal neuron differentiation ( J:161853 )

• neurons exhibit defective neurite outgrowth compared with wild-type neurons

impaired fibroblast cell migration ( J:161853 )

• mouse embryonic fibroblasts fail to migrate to the wound site in an in vitro scratch test unlike wild-type cells

abnormal neuronal migration ( J:161853 )

• neurons fail to migrate along the rostral migratory stream unlike in wild-type mice

growth/size/body

decreased body weight ( J:161853 )

• at P14

Genotype
MGI:4818691

cn2

• Allelic Composition: Mrtfb^tm2.1Eno/Mrtfb^tm2.1Eno; Tg(GFAP-cre)25Mes/0
• Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

normal phenotype

no abnormal phenotype detected ( J:161853 )

• mice are normal