Analysis Tools
immune system
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• cultured tamoxifen-treated DN1, DN2, and DN3 thymocytes differentiate into natural killer-like cells and kill stromal feeder cells unlike similarly treated wild-type thymocytes
• cultured spleen and thymus cells treated with tamoxifen exhibit differentiation into induced T to natural killer cells (ITNK) unlike cells from similarly treated wild-type cells
• tamoxifen-treated thymocytes transplanted into Rag2 Il2rg null mice exhibit an increase in ITNK cells compared with mice transplanted with similarly treated wild-type mice
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neoplasm
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• reprogrammed induced T to natural killer cells (ITNK) transplanted into Rag2 Il2rg null suppress metastasis of transplanted B16F10 melanoma cells
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hematopoietic system
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• cultured tamoxifen-treated DN1, DN2, and DN3 thymocytes differentiate into natural killer-like cells and kill stromal feeder cells unlike similarly treated wild-type thymocytes
• cultured spleen and thymus cells treated with tamoxifen exhibit differentiation into induced T to natural killer cells (ITNK) unlike cells from similarly treated wild-type cells
• tamoxifen-treated thymocytes transplanted into Rag2 Il2rg null mice exhibit an increase in ITNK cells compared with mice transplanted with similarly treated wild-type mice
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