Phenotypes associated with this allele

• Allele Symbol: Slc15a1^tm1Dgen
• Allele Name: targeted mutation 1, Deltagen
• Allele ID: MGI:4818784
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc15a1^tm1Dgen/Slc15a1^tm1Dgen	involves: 129P2/OlaHsd * C57BL/6	MGI:4818785

Genotype
MGI:4818785

hm1

• Allelic Composition: Slc15a1^tm1Dgen/Slc15a1^tm1Dgen
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal intestinal absorption ( J:162297 )

• glycylsarcosine uptake by everted jejunal rings is only 22% of controls

• peptide permeability is only 5% of controls in whole animal studies

• peak circulating concentrations of glycylsarcosine are substantially reduced relative to controls after gastric lavage

• mice otherwise display a normal phenotype