Phenotypes associated with this allele

• Allele Symbol: As3mt^tm1Djth
• Allele Name: targeted mutation 1, David Thomas
• Allele ID: MGI:4818883
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	As3mt^tm1Djth/As3mt^tm1Djth	involves: 129S6/SvEvTac * C57BL/6	MGI:4818884

Genotype
MGI:4818884

hm1

• Allelic Composition: As3mt^tm1Djth/As3mt^tm1Djth
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal xenobiotic pharmacokinetics ( J:162148 )

• two hours after oral administartion of arsenate the concentrations of inorganic arsenic, methyl arsenic and dimethyl arsenic differs in livers

• decreased methylarsenic levels in urine compared to % in wild-type after oral administartion of arsenate

liver/biliary system

abnormal liver physiology ( J:162148 )

• whole body clearance of arsenate is substantially slower than in wild-type