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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Itga5tm2Hyn
targeted mutation 2, Richard Hynes
MGI:4818931
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Itga5tm2Hyn/Itga5tm2Hyn involves: 129S1/Sv * 129X1/SvJ MGI:4820817
cn2
 		Itga5tm2Hyn/Itga5tm2Hyn
Tg(Tek-cre)1Ywa/0 		B6.Cg-Tg(Tek-cre)1Ywa Itga5tm2Hyn MGI:4818938
cn3
 		Itga5tm1Hyn/Itga5tm2Hyn
Tg(H2-K1-tsA58)6Kio/0
Tg(Tek-cre)1Ywa/0 		involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca * SJL MGI:4818936
cn4
 		Itga5tm2Hyn/Itga5tm2Hyn
Itgavtm2Hyn/Itgavtm2Hyn
Tg(H2-K1-tsA58)6Kio/0 		involves: 129 * C57BL/6 * SJL MGI:4818937
cn5
 		Itga5tm1Hyn/Itga5tm2Hyn
Tg(Tek-cre)1Ywa/0 		involves: 129 * C57BL/6 * SJL MGI:4818935
cn6
 		Gt(ROSA)26Sortm1Sho/0
Itga5tm2Hyn/Itga5tm1Hyn
Itgavtm2Hyn/Itgav+
Tg(Tek-cre)1Ywa/0 		involves: 129 * C57BL/6 * SJL MGI:4818939
cn7
 		Gt(ROSA)26Sortm1Sho/0
Itga5tm2Hyn/Itga5tm1Hyn
Itgavtm1Hyn/Itgavtm2Hyn
Tg(Tek-cre)1Ywa/0 		involves: 129 * C57BL/6 * SJL MGI:4818940


Genotype
MGI:4820817
cn1
Allelic
Composition		 Itga5tm2Hyn/Itga5tm2Hyn
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga5tm2Hyn mutation (2 available); any Itga5 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuronal migration ( J:159465 )
• impaired radial migration with an accumulation of migrating neurons in the ventral region of the cortex as opposed to wild-type cortical neurons which migrate normally away from the ventricular/sub-ventricular zone to reach the cortical plate when electroporated with Cre recombinase in cortical progenitor cells in the ventricular region of cerebral cortex
abnormal cerebral cortex morphology ( J:159465 )
• in some regions along the cerebral cortex neurons form clusters and show morphological abnormalities with formation of multiple neuronal protrusions when electroporated with Cre recombinase in cortical progenitor cells in the ventricular region of cerebral cortex

cellular
abnormal neuronal migration ( J:159465 )
• impaired radial migration with an accumulation of migrating neurons in the ventral region of the cortex as opposed to wild-type cortical neurons which migrate normally away from the ventricular/sub-ventricular zone to reach the cortical plate when electroporated with Cre recombinase in cortical progenitor cells in the ventricular region of cerebral cortex




Genotype
MGI:4818938
cn2
Allelic
Composition		 Itga5tm2Hyn/Itga5tm2Hyn
Tg(Tek-cre)1Ywa/0
Genetic
Background		 B6.Cg-Tg(Tek-cre)1Ywa Itga5tm2Hyn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga5tm2Hyn mutation (2 available); any Itga5 mutation (45 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
patent ductus arteriosus ( J:161850 )
• in 90% of 10- to 20-week-old mice

cellular
patent ductus arteriosus ( J:161850 )
• in 90% of 10- to 20-week-old mice




Genotype
MGI:4818936
cn3
Allelic
Composition		 Itga5tm1Hyn/Itga5tm2Hyn
Tg(H2-K1-tsA58)6Kio/0
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga5tm1Hyn mutation (1 available); any Itga5 mutation (45 available)
Itga5tm2Hyn mutation (2 available); any Itga5 mutation (45 available)
Tg(H2-K1-tsA58)6Kio mutation (2 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell adhesion ( J:161850 )
• endothelial cells showed reduced adhesion to fibronectin




Genotype
MGI:4818937
cn4
Allelic
Composition		 Itga5tm2Hyn/Itga5tm2Hyn
Itgavtm2Hyn/Itgavtm2Hyn
Tg(H2-K1-tsA58)6Kio/0
Genetic
Background		 involves: 129 * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga5tm2Hyn mutation (2 available); any Itga5 mutation (45 available)
Itgavtm2Hyn mutation (2 available); any Itgav mutation (53 available)
Tg(H2-K1-tsA58)6Kio mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell adhesion ( J:161850 )
• endothelial cells when transiently transfected with cre, have reduced adhesion to fibronectin




Genotype
MGI:4818935
cn5
Allelic
Composition		 Itga5tm1Hyn/Itga5tm2Hyn
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: 129 * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga5tm1Hyn mutation (1 available); any Itga5 mutation (45 available)
Itga5tm2Hyn mutation (2 available); any Itga5 mutation (45 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:4818939
cn6
Allelic
Composition		 Gt(ROSA)26Sortm1Sho/0
Itga5tm2Hyn/Itga5tm1Hyn
Itgavtm2Hyn/Itgav+
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: 129 * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sho mutation (4 available); any Gt(ROSA)26Sor mutation (967 available)
Itga5tm1Hyn mutation (1 available); any Itga5 mutation (45 available)
Itga5tm2Hyn mutation (2 available); any Itga5 mutation (45 available)
Itgavtm2Hyn mutation (2 available); any Itgav mutation (53 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:161850 )
• at P21 fewer mice are alive than wild type

cardiovascular system
patent ductus arteriosus ( J:161850 )
• in several of the mice
ventricular septal defect ( J:161850 )
• ventricular septation defects

cellular
patent ductus arteriosus ( J:161850 )
• in several of the mice




Genotype
MGI:4818940
cn7
Allelic
Composition		 Gt(ROSA)26Sortm1Sho/0
Itga5tm2Hyn/Itga5tm1Hyn
Itgavtm1Hyn/Itgavtm2Hyn
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: 129 * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sho mutation (4 available); any Gt(ROSA)26Sor mutation (967 available)
Itga5tm1Hyn mutation (1 available); any Itga5 mutation (45 available)
Itga5tm2Hyn mutation (2 available); any Itga5 mutation (45 available)
Itgavtm1Hyn mutation (1 available); any Itgav mutation (53 available)
Itgavtm2Hyn mutation (2 available); any Itgav mutation (53 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, complete penetrance ( J:161850 )
• die at E14.5 of severe dorsal edema and sometimes hemorrhage

cardiovascular system
vascular ring ( J:161850 )
• aorta vascular ring
abnormal ascending aorta morphology ( J:161850 )
• absent ascending aorta
patent ductus arteriosus ( J:161850 )
• in one of two surviving mice
ventricular septal defect ( J:161850 )
• ventricular septation defects

cellular
patent ductus arteriosus ( J:161850 )
• in one of two surviving mice




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Send questions and comments to User Support. 		last database update
07/02/2024
MGI 6.13 		The Jackson Laboratory