Phenotypes associated with this allele

• Allele Symbol: Tg(Emu-FGFR3)A5Wmk
• Allele Name: transgene insertion A5, W Michael Kuehl
• Allele ID: MGI:4818998
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Igh^tm1(Myc)Janz/Igh^+ Tg(Emu-FGFR3)A5Wmk/0	involves: 129X1/SvJ * C57BL/6 * FVB/N	MGI:4819006
tg2	Tg(Emu-FGFR3)A5Wmk/0	FVB/N-Tg(Emu-FGFR3)A5Wmk	MGI:4819004

Genotype
MGI:4819006

cx1

• Allelic Composition: Igh^tm1(Myc)Janz/Igh⁺; Tg(Emu-FGFR3)A5Wmk/0
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

abnormal tumor morphology ( J:160845 )

• tumors are less differentiated than tumors from Igh^tm1(Myc)Janz heterozygotes

increased tumor incidence ( J:160845 )

• 98% of mice developed tumors at a median age of 156 days unlike wild-type mice

increased B cell derived lymphoma incidence ( J:160845 )

increased plasmacytoma incidence ( J:160845 )

• 1 tumor exhibits plasmacytoid differentiation

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
multiple myeloma		DOID:9538	OMIM:254500	J:160845

Genotype
MGI:4819004

tg2

• Allelic Composition: Tg(Emu-FGFR3)A5Wmk/0
• Genetic Background: FVB/N-Tg(Emu-FGFR3)A5Wmk

immune system

lymphoid hyperplasia ( J:160845 )

• in 10 of 32 mice