Phenotypes associated with this allele

• Allele Symbol: Tg(Thy1-PSEN1*G384A)45Jckr
• Allele Name: transgene insertion 45, Mathias Jucker
• Allele ID: MGI:4819105
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(Thy1-APPDutch)#Jckr/0 Tg(Thy1-PSEN1*G384A)45Jckr/0	involves: C57BL/6 * C57BL/6J * DBA/2	MGI:4819108
cx2	Tg(Thy1-APPDutch)#Jckr/0 Tg(Thy1-PSEN1*G384A)45Jckr/0	involves: C57BL/6 * DBA/2	MGI:4819594

Genotype
MGI:4819108

cx1

• Allelic Composition: Tg(Thy1-APPDutch)#Jckr/0; Tg(Thy1-PSEN1*G384A)45Jckr/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

amyloid beta deposits ( J:92796 )

• starting at 12 weeks of age parenchymal amyloid in the neocortex and hippocampus

• at 10 months, massive diffuse and compact parenchymal amyloid are found in virtually all brain regions

cerebral amyloid angiopathy ( J:92796 )

homeostasis/metabolism

amyloidosis ( J:92796 )

amyloid beta deposits ( J:92796 )

• starting at 12 weeks of age parenchymal amyloid in the neocortex and hippocampus

• at 10 months, massive diffuse and compact parenchymal amyloid are found in virtually all brain regions

cerebral amyloid angiopathy ( J:92796 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cerebral amyloid angiopathy		DOID:9246		J:92796

Genotype
MGI:4819594

cx2

• Allelic Composition: Tg(Thy1-APPDutch)#Jckr/0; Tg(Thy1-PSEN1*G384A)45Jckr/0
• Genetic Background: involves: C57BL/6 * DBA/2

nervous system

amyloid beta deposits ( J:162531 )

homeostasis/metabolism

amyloidosis ( J:162531 )

• massive parenchymal amyloidosis is observed throughout the entire brain with the exception of the cerellebum

• modest vascular amyloid also present

amyloid beta deposits ( J:162531 )