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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cd40lgm1Btlr
mutation 1, Bruce Beutler
MGI:4819117
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cd40lgm1Btlr/Cd40lgm1Btlr C57BL/6J-Cd40lgm1Btlr MGI:4819119
hm2
 		Cd40lgm1Btlr/Cd40lgm1Btlr involves: C57BL/6J MGI:5429185
ot3
 		Cd40lgm1Btlr/Y involves: C57BL/6J MGI:5429193


Genotype
MGI:4819119
hm1
Allelic
Composition		 Cd40lgm1Btlr/Cd40lgm1Btlr
Genetic
Background		 C57BL/6J-Cd40lgm1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40lgm1Btlr mutation (1 available); any Cd40lg mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:162147 )
N
• normal T cell independent IgM responses and serum IgA levels
• normal frequencies and surface phenotypes of T and B cells in peripheral blood
decreased IgG level ( J:162147 )
• failure of the T cell dependent IgG response to the model antigen beta-galactosidase encoded by recombinant Semliki Forest Virus (rSFV)

hematopoietic system
decreased IgG level ( J:162147 )
• failure of the T cell dependent IgG response to the model antigen beta-galactosidase encoded by recombinant Semliki Forest Virus (rSFV)




Genotype
MGI:5429185
hm2
Allelic
Composition		 Cd40lgm1Btlr/Cd40lgm1Btlr
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40lgm1Btlr mutation (1 available); any Cd40lg mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:185495 )
N
• mice exhibit normal peripheral blood lymphocytes
• mice exhibit a normal response to NP-Ficoll
abnormal class switch recombination ( J:185495 )
• mice exhibit reduced class-switch antibody response in response to recombinant Semliki Forest virus (SFV) encoded antigen compared with control mice
decreased IgG level ( J:185495 )
• response in response to recombinant Semliki Forest virus (SFV) encoded antigen

hematopoietic system
abnormal class switch recombination ( J:185495 )
• mice exhibit reduced class-switch antibody response in response to recombinant Semliki Forest virus (SFV) encoded antigen compared with control mice
decreased IgG level ( J:185495 )
• response in response to recombinant Semliki Forest virus (SFV) encoded antigen




Genotype
MGI:5429193
ot3
Allelic
Composition		 Cd40lgm1Btlr/Y
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40lgm1Btlr mutation (1 available); any Cd40lg mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:185495 )
N
• mice exhibit normal peripheral blood lymphocytes
• mice exhibit a normal response to NP-Ficoll
abnormal class switch recombination ( J:185495 )
• mice exhibit reduced class-switch antibody response in response to recombinant Semliki Forest virus (SFV) encoded antigen compared with control mice
decreased IgG level ( J:185495 )
• response in response to recombinant Semliki Forest virus (SFV) encoded antigen

hematopoietic system
abnormal class switch recombination ( J:185495 )
• mice exhibit reduced class-switch antibody response in response to recombinant Semliki Forest virus (SFV) encoded antigen compared with control mice
decreased IgG level ( J:185495 )
• response in response to recombinant Semliki Forest virus (SFV) encoded antigen




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory