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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Prkcbtilc
tilcara
MGI:4819152
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Prkcbtilc/Prkcbtilc C57BL/6JSfdAnu-Prkcbtilc/AnuApb MGI:4819153
hm2
 		Prkcbtilc/Prkcbtilc involves: C57BL/6JSfdAnu MGI:5695298
ht3
 		Prkcbtilc/Prkcb+ involves: C57BL/6JSfdAnu MGI:5695300


Genotype
MGI:4819153
hm1
Allelic
Composition		 Prkcbtilc/Prkcbtilc
Genetic
Background		 C57BL/6JSfdAnu-Prkcbtilc/AnuApb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkcbtilc mutation (2 available); any Prkcb mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased IgM level ( J:104190 )
• relative to that of control mice in response to the T cell independent type 2 antigen 4-hydroxy-3-nitrophenylacetyl (NP)-Ficoll

hematopoietic system
decreased IgM level ( J:104190 )
• relative to that of control mice in response to the T cell independent type 2 antigen 4-hydroxy-3-nitrophenylacetyl (NP)-Ficoll




Genotype
MGI:5695298
hm2
Allelic
Composition		 Prkcbtilc/Prkcbtilc
Genetic
Background		 involves: C57BL/6JSfdAnu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkcbtilc mutation (2 available); any Prkcb mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:221236 )
N
• IgG1 and IgG total levels are comparable to controls
• normal T cell dependent antibody responses
decreased B cell proliferation ( J:221236 )
• spleen cells show reduced entry of B cells into the cell cycle after B cell receptor stimulation
decreased B-1a cell number ( J:221236 )
• near absence of B-1a lymphocytes in the peritoneal cavity of homozygotes
abnormal humoral immune response ( J:221236 )
• significantly reduced antibody to TI-2 antigens
decreased IgG3 level ( J:221236 )
• basal levels decreased 75%
decreased IgM level ( J:221236 )
• 75% reduction in IgM levels in un-immunized homozygous mice

hematopoietic system
decreased B cell proliferation ( J:221236 )
• spleen cells show reduced entry of B cells into the cell cycle after B cell receptor stimulation
decreased B-1a cell number ( J:221236 )
• near absence of B-1a lymphocytes in the peritoneal cavity of homozygotes
decreased IgG3 level ( J:221236 )
• basal levels decreased 75%
decreased IgM level ( J:221236 )
• 75% reduction in IgM levels in un-immunized homozygous mice

cellular
decreased B cell proliferation ( J:221236 )
• spleen cells show reduced entry of B cells into the cell cycle after B cell receptor stimulation




Genotype
MGI:5695300
ht3
Allelic
Composition		 Prkcbtilc/Prkcb+
Genetic
Background		 involves: C57BL/6JSfdAnu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkcbtilc mutation (2 available); any Prkcb mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal humoral immune response ( J:221236 )
• intermediate response to TI-2 antigens between that of homozygous and wild-type mice
decreased IgG3 level ( J:221236 )
• basal levels decreased 75%
decreased IgM level ( J:221236 )
• 50% reduction in IgM levels in un-immunized heterozygous mice

hematopoietic system
decreased IgG3 level ( J:221236 )
• basal levels decreased 75%
decreased IgM level ( J:221236 )
• 50% reduction in IgM levels in un-immunized heterozygous mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
08/02/2024
MGI 6.24 		The Jackson Laboratory