Phenotypes associated with this allele

• Allele Symbol: Tg(STIL-TAL1)A5(3)Alpa
• Allele Name: transgene insertion A5(3), Peter Alpan
• Allele ID: MGI:4819165
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(Lck-LMO1)11Sjk/0 Tg(STIL-TAL1)A5(3)Alpa/0	involves: C3H * C3H/HeRos * C57BL/6 * C57BL/10Ros	MGI:4819172
tg2	Tg(STIL-TAL1)A5(3)Alpa/0	involves: C3H/HeRos * C57BL/10Ros	MGI:4819173

Genotype
MGI:4819172

cx1

• Allelic Composition: Tg(Lck-LMO1)11Sjk/0; Tg(STIL-TAL1)A5(3)Alpa/0
• Genetic Background: involves: C3H * C3H/HeRos * C57BL/6 * C57BL/10Ros

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

enlarged thymus ( J:40868 )

increased T cell derived lymphoma incidence ( J:40868 )

• 95% of mice develop aggressive T cell leukemia/lymphomas within 6 months

enlarged spleen ( J:40868 )

decreased bone marrow cell number ( J:40868 )

• lymphoblasts replace bone marrow

decreased erythrocyte cell number ( J:40868 )

thrombocytopenia ( J:40868 )

increased leukocyte cell number ( J:40868 )

• in some mice

neoplasm

increased T cell derived lymphoma incidence ( J:40868 )

• 95% of mice develop aggressive T cell leukemia/lymphomas within 6 months

increased leukemia incidence ( J:40868 )

• 95% of mice develop aggressive T cell leukemia/lymphomas within 6 months

behavior/neurological

lethargy ( J:40868 )

liver/biliary system

enlarged liver ( J:40868 )

respiratory system

respiratory distress ( J:40868 )

immune system

enlarged thymus ( J:40868 )

increased T cell derived lymphoma incidence ( J:40868 )

• 95% of mice develop aggressive T cell leukemia/lymphomas within 6 months

enlarged spleen ( J:40868 )

increased leukocyte cell number ( J:40868 )

• in some mice

enlarged lymph nodes ( J:40868 )

• peripheral

abnormal inflammatory response ( J:40868 )

• mice exhibit widespread organ infiltration including liver, kidney, lung, and bone marrow

endocrine/exocrine glands

enlarged thymus ( J:40868 )

increased T cell derived lymphoma incidence ( J:40868 )

• 95% of mice develop aggressive T cell leukemia/lymphomas within 6 months

growth/size/body

enlarged liver ( J:40868 )

enlarged spleen ( J:40868 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
acute lymphoblastic leukemia		DOID:9952	OMIM:247640 OMIM:613065	J:40868

Genotype
MGI:4819173

tg2

• Allelic Composition: Tg(STIL-TAL1)A5(3)Alpa/0
• Genetic Background: involves: C3H/HeRos * C57BL/10Ros

neoplasm

neoplasm ( J:40868 )

N • mice do not develop T cell malignancy by 6 months of age