All Phenotypes Tg(Lck-LMO1)11Sjk MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ccnc^tm1.1Pisc/Ccnc^tm1.1Pisc Tg(Lck-LMO1)11Sjk/0 Tg(Mx1-cre)1Cgn/0	Not Specified	MGI:5697722
cx2	Tg(Lck-LMO1)11Sjk/0 Tg(STIL-TAL1)A5(3)Alpa/0	involves: C3H * C3H/HeRos * C57BL/6 * C57BL/10Ros	MGI:4819172
tg3	Tg(Lck-LMO1)11Sjk/0	involves: C3H * C57BL/6	MGI:4819174

Allelic Composition	Ccnc^tm1.1Pisc/Ccnc^tm1.1Pisc Tg(Lck-LMO1)11Sjk/0 Tg(Mx1-cre)1Cgn/0
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnc^tm1.1Pisc mutation (0 available); any Ccnc mutation (27 available)
Tg(Lck-LMO1)11Sjk mutation (0 available)
Tg(Mx1-cre)1Cgn mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased T cell derived lymphoma incidence ( J:217695 )

• strongly increased tumour incidence of T-ALL with elevated ICN1 levels in mutant tumors

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:217695 )

• strongly increased tumour incidence of T-ALL with elevated ICN1 levels in mutant tumors

immune system

increased T cell derived lymphoma incidence ( J:217695 )

• strongly increased tumour incidence of T-ALL with elevated ICN1 levels in mutant tumors

hematopoietic system

increased T cell derived lymphoma incidence ( J:217695 )

• strongly increased tumour incidence of T-ALL with elevated ICN1 levels in mutant tumors

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

enlarged thymus ( J:40868 )

increased T cell derived lymphoma incidence ( J:40868 )

• 95% of mice develop aggressive T cell leukemia/lymphomas within 6 months

enlarged spleen ( J:40868 )

decreased bone marrow cell number ( J:40868 )

• lymphoblasts replace bone marrow

decreased erythrocyte cell number ( J:40868 )

thrombocytopenia ( J:40868 )

increased leukocyte cell number ( J:40868 )

• in some mice

neoplasm

increased T cell derived lymphoma incidence ( J:40868 )

• 95% of mice develop aggressive T cell leukemia/lymphomas within 6 months

increased leukemia incidence ( J:40868 )

• 95% of mice develop aggressive T cell leukemia/lymphomas within 6 months

behavior/neurological

lethargy ( J:40868 )

liver/biliary system

enlarged liver ( J:40868 )

respiratory system

respiratory distress ( J:40868 )

immune system

enlarged thymus ( J:40868 )

increased T cell derived lymphoma incidence ( J:40868 )

• 95% of mice develop aggressive T cell leukemia/lymphomas within 6 months

enlarged spleen ( J:40868 )

increased leukocyte cell number ( J:40868 )

• in some mice

enlarged lymph nodes ( J:40868 )

• peripheral

abnormal inflammatory response ( J:40868 )

• mice exhibit widespread organ infiltration including liver, kidney, lung, and bone marrow

endocrine/exocrine glands

enlarged thymus ( J:40868 )

increased T cell derived lymphoma incidence ( J:40868 )

• 95% of mice develop aggressive T cell leukemia/lymphomas within 6 months

growth/size/body

enlarged liver ( J:40868 )

enlarged spleen ( J:40868 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
acute lymphoblastic leukemia		DOID:9952	OMIM:247640 OMIM:613065	J:40868

Allelic Composition	Tg(Lck-LMO1)11Sjk/0
Genetic Background	involves: C3H * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:40868 )

N	• mice do not develop T cell malignancy by 6 months of age

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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