cellular
• mice administered tamoxifen from P26 to P30 show impaired adult oligodendrocyte progenitor cell differentiation, with mice showing reduced mature CC1+ oligodendrocytes at P42
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nervous system
• mice administered tamoxifen and then treated with lysolecithin to induce demyelination show less MBP protein in the corpus callosum, reduced number of CC1+-differentiating oligodendrocytes, and fewer myelinated axons in the lesions indicating decreased remyelination and oligodendrocyte regeneration; this is also seen in spinal cord
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