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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(PMP22)C61Clh
transgene insertion C61, Clare Huxley
MGI:4819405
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Ccl2tm1Rol/Ccl2+
Tg(PMP22)C61Clh/0 		involves: 129S4/SvJae * C57BL/6J * CBA/Ca MGI:4819493
cx2
 		Ccl2tm1Rol/Ccl2tm1Rol
Tg(PMP22)C61Clh/0 		involves: 129S4/SvJae * C57BL/6J * CBA/Ca MGI:4819494
tg3
 		Tg(PMP22)C61Clh/0 B6.Cg-Tg(PMP22)C61Clh MGI:4819492


Genotype
MGI:4819493
cx1
Allelic
Composition		 Ccl2tm1Rol/Ccl2+
Tg(PMP22)C61Clh/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccl2tm1Rol mutation (2 available); any Ccl2 mutation (25 available)
Tg(PMP22)C61Clh mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
demyelination ( J:158350 )
• myelin phenotype is improved compared to in Tg(PMP22)C61Clh mice

behavior/neurological

immune system
increased macrophage cell number ( J:158350 )
• in the femoral quadriceps nerves at 2 and 6 months of age that is not as severe Tg(PMP22)C61Clh mice

hematopoietic system
increased macrophage cell number ( J:158350 )
• in the femoral quadriceps nerves at 2 and 6 months of age that is not as severe Tg(PMP22)C61Clh mice




Genotype
MGI:4819494
cx2
Allelic
Composition		 Ccl2tm1Rol/Ccl2tm1Rol
Tg(PMP22)C61Clh/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccl2tm1Rol mutation (2 available); any Ccl2 mutation (25 available)
Tg(PMP22)C61Clh mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
demyelination ( J:158350 )
• myelin phenotype is improved compared to in Tg(PMP22)C61Clh mice
abnormal action potential ( J:158350 )
• mice exhibit a reduced amplitude of compound action potential and a prolonged duration compared with wild-type mice but not as severely as in Tg(PMP22)C61Clh mice
decreased nerve conduction velocity ( J:158350 )
• not as severely as in Tg(PMP22)C61Clh mice

behavior/neurological
abnormal grip strength ( J:158350 )
• grip strength is improved compared to in Tg(PMP22)C61Clh mice

immune system
increased macrophage cell number ( J:158350 )
• in the femoral quadriceps nerves at 2 and 6 months of age that is not as severe Tg(PMP22)C61Clh mice

hematopoietic system
increased macrophage cell number ( J:158350 )
• in the femoral quadriceps nerves at 2 and 6 months of age that is not as severe Tg(PMP22)C61Clh mice




Genotype
MGI:4819492
tg3
Allelic
Composition		 Tg(PMP22)C61Clh/0
Genetic
Background		 B6.Cg-Tg(PMP22)C61Clh
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal action potential ( J:158350 )
• mice exhibit a reduced amplitude of compound action potential and a prolonged duration compared with wild-type mice

behavior/neurological

immune system
increased macrophage cell number ( J:158350 )
• in the femoral quadriceps nerves at 2 and 6 months of age

hematopoietic system
increased macrophage cell number ( J:158350 )
• in the femoral quadriceps nerves at 2 and 6 months of age

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Charcot-Marie-Tooth disease type 1A DOID:0110148 OMIM:118220
 J:158350




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory