Analysis Tools
mortality/aging
|
• adult mice die 7 days after tamoxifen treatment
|
digestive/alimentary system
|
• tamoxifen-treated mice exhibit reduced cell proliferation with abnormal nuclei and mitotic increased nuclear area compared with wild-type mice
|
|
• tamoxifen-treated mice exhibit atrophy of the small intestine compared with wild-type mice
|
|
• 6 days after tamoxifen treatment, mice exhibit a greater than 80% loss of villus epithelium compared with wild-type mice
however, no increase in apoptosis is observed
|
cellular
|
• tamoxifen-treated mouse embryonic fibroblasts exhibit supernumerary centrosomes compared with similarly treated wild-type cells
|
|
• tamoxifen-treated mouse embryonic fibroblasts stimulated with serum exhibit abnormal nuclei including binuclear, multi-lobed, and donut-shaped nuclei compared to similarly treated wild-type cells
|
|
• tamoxifen-treated mouse embryonic fibroblasts exhibit a delayed entry into mitosis (G2 delay) compared with similarly treated wild-type mice
• tamoxifen-treated mouse embryonic fibroblasts exhibit mitotic errors including chromatin bridges, failed nuclear segregation, cytokinesis failure, chaotic multipolar spindles, and supernumerary centrosomes compared with similarly treated wild-type cells
|
|
• following tamoxifen treatment, mouse embryonic fibroblasts exhibit severely impaired proliferation compared with similarly treated wild-type cells
|
|
• tamoxifen-treated mice exhibit reduced cell proliferation with abnormal nuclei and mitotic increased nuclear area compared with wild-type mice
|
