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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Eef2ktm1Agry
targeted mutation 1, Alexey G Ryazanov
MGI:4819586
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Eef2ktm1Agry/Eef2ktm1Agry B6.Cg-Eef2ktm1Agry MGI:5610137
hm2
Eef2ktm1Agry/Eef2ktm1Agry involves: C57BL/6 MGI:6454346
hm3
Eef2ktm1Agry/Eef2ktm1Agry Not Specified MGI:4819606


Genotype
MGI:5610137
hm1
Allelic
Composition
Eef2ktm1Agry/Eef2ktm1Agry
Genetic
Background
B6.Cg-Eef2ktm1Agry
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eef2ktm1Agry mutation (0 available); any Eef2k mutation (43 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• at 17-21 months of age many of the large antral follicles contain unhealthy looking irregular shaped oocytes
• at 20 months of age ovaries contain follicles at various developmental stages and corpora lutea, unlike wild-type females that lack follicles by this age
• many of the aged ovaries display preovulatory-like follicles that are not seen in age-matched wild-type females
• about 2 fold higher at 15 months of age
• about 2 fold and 3 fold higher at 6 and 15 months of age, respectively
• about 2 fold higher number of secondary follicles at 15 months of age
• 88% of ovaries from 17-21 month old females still have large antral follicles with oocytes compared to only 33% of controls
• about 2 fold higher number of antral follicles at 15 months of age
• impaired regulation of follicle degeneration and apoptosis
• significant reduction of pyknosis in the antral follicles at 6 months of age
• hypertrophy of uterine tissue at 20 months of age
• oocytes could be retrieved following superovulation of 15 month old females unlike in age-matched wild-type females
• significantly prolonged leading to an increase in the duration of the estrous cycle
• 18% of females are able to get pregnant at 12-16 months of age but are unable to deliver viable pups

cellular
• at 17-21 months of age many of the large antral follicles contain unhealthy looking irregular shaped oocytes
• MEFs are resistant to doxorubicin and H2O2 induced apoptosis (J:208406)
• decrease in levels of cleaved caspase-3 in the estrus phase in 2 month old mice (J:208406)
• significant reduction of pyknosis in the antral follicles at 6 months of age (J:208406)
• granulosa cells are resistant to TNF induced apoptosis (J:208406)

homeostasis/metabolism
• MEFs are resistant to doxorubicin and H2O2 induced apoptosis

endocrine/exocrine glands
• at 20 months of age ovaries contain follicles at various developmental stages and corpora lutea, unlike wild-type females that lack follicles by this age
• many of the aged ovaries display preovulatory-like follicles that are not seen in age-matched wild-type females
• about 2 fold higher at 15 months of age
• about 2 fold and 3 fold higher at 6 and 15 months of age, respectively
• about 2 fold higher number of secondary follicles at 15 months of age
• 88% of ovaries from 17-21 month old females still have large antral follicles with oocytes compared to only 33% of controls
• about 2 fold higher number of antral follicles at 15 months of age
• impaired regulation of follicle degeneration and apoptosis
• significant reduction of pyknosis in the antral follicles at 6 months of age




Genotype
MGI:6454346
hm2
Allelic
Composition
Eef2ktm1Agry/Eef2ktm1Agry
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eef2ktm1Agry mutation (0 available); any Eef2k mutation (43 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• reduced discrimination index in virtual object recognition test with stationary shapes
• normal behavior index in novel object recognition test
• normal behavior index in virtual object recognition test when presenting moving different shapes in intertrial delay




Genotype
MGI:4819606
hm3
Allelic
Composition
Eef2ktm1Agry/Eef2ktm1Agry
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eef2ktm1Agry mutation (0 available); any Eef2k mutation (43 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• resveratrol-treated mice fail to inhibit injury-induced choroidal neovascularization unlike in similarly treated wild-type





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory