Phenotypes associated with this allele

• Allele Symbol: Trp53^tm2.1Dgj
• Allele Name: targeted mutation 2.1, David G Johnson
• Allele ID: MGI:4819617
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trp53^tm2.1Dgj/Trp53^tm2.1Dgj	involves: SKH	MGI:4819638

Genotype
MGI:4819638

hm1

• Allelic Composition: Trp53^tm2.1Dgj/Trp53^tm2.1Dgj
• Genetic Background: involves: SKH

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased cellular sensitivity to ionizing radiation ( J:162466 )

• ionizing radiation-exposed mice exhibit increased apoptosis in the intestine compared with similarly treated Trp53^tm1.1Dgj homozygotes

• however, there is no difference compared with wild-type mice

increased cellular sensitivity to ultraviolet irradiation ( J:162466 )

• UV-exposed mice exhibit increased apoptosis in the skin compared with similarly treated wild-type mice and Trp53^tm1.1Dgj homozygotes

neoplasm

neoplasm ( J:162466 )

N • mice exhibit normal spontaneous and UV-induced tumorigenesis