All Phenotypes Tg(TRP53)4Dgj MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(TRP53)4Dgj
transgene insertion 4, David G Johnson
MGI:4819619

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(TRP53)4Dgj/0 Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129S2/SvPas * FVB	MGI:4819639

Allelic Composition	Tg(TRP53)4Dgj/0 Trp53^tm1Tyj/Trp53^tm1Tyj
Genetic Background	involves: 129S2/SvPas * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(TRP53)4Dgj mutation (0 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased lymphoma incidence ( J:162466 )

• development of early lymphomas in Trp53^tm1Tyj homozygotes is rescued

increased osteosarcoma incidence ( J:162466 )

• more common than in Tg(TRP53*R72P)7Dgj mice

cellular

increased cellular sensitivity to ultraviolet irradiation ( J:162466 )

• UV-exposed mice exhibit increased apoptosis in the skin compared with similarly treated Tg(TRP53*R72P)7Dgj mice

skeleton

increased osteosarcoma incidence ( J:162466 )

• more common than in Tg(TRP53*R72P)7Dgj mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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