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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(TRP53*R72P)7Dgj
transgene insertion 7, David G Johnson
MGI:4819620
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Tg(TRP53*R72P)7Dgj/0
Trp53tm1Tyj/Trp53tm1Tyj 		involves: 129S2/SvPas * FVB MGI:4819640


Genotype
MGI:4819640
cx1
Allelic
Composition		 Tg(TRP53*R72P)7Dgj/0
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background		 involves: 129S2/SvPas * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(TRP53*R72P)7Dgj mutation (0 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased lymphoma incidence ( J:162466 )
• development of early lymphomas in Trp53tm1Tyj homozygotes is rescued

cellular
decreased cellular sensitivity to ultraviolet irradiation ( J:162466 )
• UV-exposed mice exhibit increased apoptosis in the skin compared with similarly treated Tg(TRP53)4Dgj mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory