Phenotypes associated with this allele

• Allele Symbol: Tg(Tnnt2-TNNT2*R92Q)M-2Ajm
• Allele Name: transgene insertion M-2, Ali J Marian
• Allele ID: MGI:4819719
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Tnnt2-TNNT2*R92Q)M-2Ajm/0	involves: C3H * C57BL/6 * ICR	MGI:4819727

Genotype
MGI:4819727

tg1

• Allelic Composition: Tg(Tnnt2-TNNT2*R92Q)M-2Ajm/0
• Genetic Background: involves: C3H * C57BL/6 * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal myocardial fiber morphology ( J:117554 )

• cardiomyocyte disarray

• this line displays the most extensive disarray relative to other lines carrying the same transgene

cardiac interstitial fibrosis ( J:117554 )

• increase in interstitial collagen

abnormal cardiovascular system physiology ( J:117554 )

• the decrease in the ratio of peak early velocity to peak atrial velocity is indicative of left ventricular diastolic dysfunction

abnormal blood flow velocity ( J:117554 )

• increase in mitral valve peak atrial velocity and a decrease in the ratio of peak early velocity to peak atrial velocity compared to controls

muscle

abnormal myocardial fiber morphology ( J:117554 )

• cardiomyocyte disarray

• this line displays the most extensive disarray relative to other lines carrying the same transgene

cellular

cardiac interstitial fibrosis ( J:117554 )

• increase in interstitial collagen

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hypertrophic cardiomyopathy 2		DOID:0110308	OMIM:115195	J:117554