mortality/aging
N |
• no change in survival is detected in mice up to 2 years of age
|
cardiovascular system
N |
• no increase in heart weight is detected
|
• cardiomyocyte disarray
(J:161899)
• cardiomyocyte disarray comprising about 27% of the myocardium compared to about 4% in controls
(J:162685)
|
• decrease in left ventricular end systolic diameters
|
• increase in the collagen volume fraction
(J:161899)
• in 2/3 of 3 to 12 month old mice
(J:162685)
• treatment with Losartan significantly reduces interstitial fibrillar collagen
(J:162685)
|
• increase in left ventricular systolic function
|
muscle
• cardiomyocyte disarray
(J:161899)
• cardiomyocyte disarray comprising about 27% of the myocardium compared to about 4% in controls
(J:162685)
|
cellular
• increase in the collagen volume fraction
(J:161899)
• in 2/3 of 3 to 12 month old mice
(J:162685)
• treatment with Losartan significantly reduces interstitial fibrillar collagen
(J:162685)
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
hypertrophic cardiomyopathy 2 | DOID:0110308 |
OMIM:115195 |
J:161899 , J:162685 |