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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Myh6-TNNT2*R92Q)#Ajm
transgene insertion, Ali J Marian
MGI:4819720
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Myh6-TNNT2*R92Q)#Ajm/0 involves: C3H * C57BL/6 * ICR MGI:4819722


Genotype
MGI:4819722
tg1
Allelic
Composition
Tg(Myh6-TNNT2*R92Q)#Ajm/0
Genetic
Background
involves: C3H * C57BL/6 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• no change in survival is detected in mice up to 2 years of age

cardiovascular system
N
• no increase in heart weight is detected
• cardiomyocyte disarray (J:161899)
• cardiomyocyte disarray comprising about 27% of the myocardium compared to about 4% in controls (J:162685)
• decrease in left ventricular end systolic diameters
• increase in the collagen volume fraction (J:161899)
• in 2/3 of 3 to 12 month old mice (J:162685)
• treatment with Losartan significantly reduces interstitial fibrillar collagen (J:162685)
• increase in left ventricular systolic function

muscle
• cardiomyocyte disarray (J:161899)
• cardiomyocyte disarray comprising about 27% of the myocardium compared to about 4% in controls (J:162685)

cellular
• increase in the collagen volume fraction (J:161899)
• in 2/3 of 3 to 12 month old mice (J:162685)
• treatment with Losartan significantly reduces interstitial fibrillar collagen (J:162685)

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hypertrophic cardiomyopathy 2 DOID:0110308 OMIM:115195
J:161899 , J:162685





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory