Phenotypes associated with this allele

• Allele Symbol: Il1rn^tm1.1Cga
• Allele Name: targeted mutation 1.1, Cem Gabay
• Allele ID: MGI:4819784
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Il1rn^tm1.1Cga/Il1rn^tm1.1Cga Lyz2^tm1(cre)Ifo/Lyz2^+	D1.Cg-Il1rn^tm1.1Cga Lyz2^tm1(cre)Ifo	MGI:4819947

Genotype
MGI:4819947

cn1

• Allelic Composition: Il1rn^tm1.1Cga/Il1rn^tm1.1Cga; Lyz2^tm1(cre)Ifo/Lyz2⁺
• Genetic Background: D1.Cg-Il1rn^tm1.1Cga Lyz2^tm1(cre)Ifo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased T cell proliferation ( J:162760 )

• in draining lymph node cells from collagen-treated wild-type mice

abnormal chemokine secretion ( J:162760 )

• myeloid cells from collage-treated mice exhibit increased CXCL1 and CXCL2 production compared with wild-type mice

increased interferon-gamma secretion ( J:162760 )

• in draining lymph node cells from collagen-treated wild-type mice

• in myeloid cells from the ankles of collagen-treated mice

increased interleukin-1 beta secretion ( J:162760 )

• in myeloid cells from the ankles of collagen-treated mice

increased interleukin-17 secretion ( J:162760 )

• in draining lymph node cells from collagen-treated wild-type mice

• in myeloid cells from the ankles of collagen-treated mice

increased interleukin-6 secretion ( J:162760 )

• in myeloid cells from the ankles of collage-treated mice

increased susceptibility to induced arthritis ( J:162760 )

• collagen treated mice exhibit earlier and more severe arthritis with increased number of paws affected, inflammation, cartilage erosion, and neutrophil infiltration compared with similarly treated wild-type mice

• draining lymph node cells from collagen-stimulated mice exhibit increased T cell proliferation, and IFN-gamma and IL17 production compared with similarly treated wild-type cells

• myeloid cells from the ankles of collagen-treated mice exhibit increased IL1b, IL6, IFNgamma, IL17, CXCL1, and CXCL2 production compared with wild-type mice

skeleton

increased susceptibility to induced arthritis ( J:162760 )

• collagen treated mice exhibit earlier and more severe arthritis with increased number of paws affected, inflammation, cartilage erosion, and neutrophil infiltration compared with similarly treated wild-type mice

• draining lymph node cells from collagen-stimulated mice exhibit increased T cell proliferation, and IFN-gamma and IL17 production compared with similarly treated wild-type cells

• myeloid cells from the ankles of collagen-treated mice exhibit increased IL1b, IL6, IFNgamma, IL17, CXCL1, and CXCL2 production compared with wild-type mice

hematopoietic system

increased T cell proliferation ( J:162760 )

• in draining lymph node cells from collagen-treated wild-type mice

cellular

increased T cell proliferation ( J:162760 )

• in draining lymph node cells from collagen-treated wild-type mice