All Phenotypes Yap1<tm1.1Dupa> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Yap1^tm1.1Dupa
targeted mutation 1.1, Duojia Pan
MGI:4819826

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Kras^tm4Tyj/Kras^tm4Tyj Yap1^tm1.1Dupa/Yap1^tm1.1Dupa Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA	MGI:4819844
cn2	Lats1^tm1Noj/Lats1^tm1Noj Lats2^tm1.1Dupa/Lats2^tm1.1Dupa Wwtr1^tm1.2Eno/Wwtr1^tm1.2Eno Yap1^tm1.1Dupa/Yap1^tm1.1Dupa	involves: 129P2/OlaHsd * 129S/SvEv * 129S2/SvPas	MGI:5660349
cn3	Nf2^tm2Gth/Nf2^tm2Gth Yap1^tm1.1Dupa/Yap1^tm1.1Dupa Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: 129P2/OlaHsd * C57BL/6 * DBA	MGI:4819842
cn4	Nf2^tm2Gth/Nf2^tm2Gth Yap1^tm1.1Dupa/Yap1⁺ Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: 129P2/OlaHsd * C57BL/6 * DBA	MGI:4819843
cn5	Yap1^tm1.1Dupa/Yap1^tm1.1Dupa Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: 129P2/OlaHsd * C57BL/6 * DBA	MGI:4819841
cn6	Yap1^tm1.1Dupa/Yap1^tm1.1Dupa Tg(Vil1-cre)997Gum/0	involves: 129P2/OlaHsd * C57BL/6J * SJL	MGI:4838643
cn7	Sav1^tm1.1Dupa/Sav1^tm1.1Dupa Yap1^tm1.1Dupa/Yap1^tm1.1Dupa Tg(Vil1-cre)997Gum/0	involves: 129P2/OlaHsd * C57BL/6J * SJL	MGI:4838644

Allelic Composition	Kras^tm4Tyj/Kras^tm4Tyj Yap1^tm1.1Dupa/Yap1^tm1.1Dupa Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm4Tyj mutation (9 available); any Kras mutation (84 available)
Speer6-ps1^{Tg(Alb-cre)21Mgn} mutation (6 available); any Speer6-ps1 mutation (4 available)
Yap1^tm1.1Dupa mutation (2 available); any Yap1 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased hepatocellular carcinoma incidence ( J:162628 )

liver/biliary system

increased hepatocellular carcinoma incidence ( J:162628 )

Allelic Composition	Lats1^tm1Noj/Lats1^tm1Noj Lats2^tm1.1Dupa/Lats2^tm1.1Dupa Wwtr1^tm1.2Eno/Wwtr1^tm1.2Eno Yap1^tm1.1Dupa/Yap1^tm1.1Dupa
Genetic Background	involves: 129P2/OlaHsd * 129S/SvEv * 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lats1^tm1Noj mutation (1 available); any Lats1 mutation (52 available)
Lats2^tm1.1Dupa mutation (1 available); any Lats2 mutation (44 available)
Wwtr1^tm1.2Eno mutation (0 available); any Wwtr1 mutation (26 available)
Yap1^tm1.1Dupa mutation (2 available); any Yap1 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal bile duct epithelium morphology ( J:223215 )

• slight proliferation of cryokeratin-positive biliary epithelial cells observed in liver following adenovirus expressing Cre recombinase (Ad-Cre) injection; in contrast to overproliferation found in homozygous Lats2^tm1.1Dupa Lats1^tm1Noj

liver/biliary system

abnormal bile duct epithelium morphology ( J:223215 )

enlarged liver ( J:223215 )

• mice develop slight hepatomegaly 8 weeks after Ad-Cre injection; in contrast to severe hepatomegaly developed by homozygous Lats2^tm1.1Dupa Lats1^tm1Noj

growth/size/body

enlarged liver ( J:223215 )

• mice develop slight hepatomegaly 8 weeks after Ad-Cre injection; in contrast to severe hepatomegaly developed by homozygous Lats2^tm1.1Dupa Lats1^tm1Noj

Allelic Composition	Nf2^tm2Gth/Nf2^tm2Gth Yap1^tm1.1Dupa/Yap1^tm1.1Dupa Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf2^tm2Gth mutation (3 available); any Nf2 mutation (65 available)
Speer6-ps1^{Tg(Alb-cre)21Mgn} mutation (6 available); any Speer6-ps1 mutation (4 available)
Yap1^tm1.1Dupa mutation (2 available); any Yap1 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

liver/biliary system

liver/biliary system phenotype ( J:162628 )

N	• liver is as enlarge as in Nf2^tm2Gth/Nf2^tm2Gth Tg(Alb-cre)21Mgn mice • bile over-proliferation observed in Nf2^tm2Gth/Nf2^tm2Gth Tg(Alb-cre)21Mgn mice is suppressed

neoplasm

neoplasm ( J:162628 )

N	• mice do not develop bile duct hamartomas or hepatocellular carcinoma unlike Nf2^tm2Gth/Nf2^tm2Gth Tg(Alb-cre)21Mgn mice

Allelic Composition	Nf2^tm2Gth/Nf2^tm2Gth Yap1^tm1.1Dupa/Yap1⁺ Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * DBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

liver/biliary system

liver/biliary system phenotype ( J:162628 )

N	• mice do not exhibit bile duct proliferation

enlarged liver ( J:162628 )

• slightly

neoplasm

neoplasm ( J:162628 )

N	• mice do not develop bile duct hamartomas or hepatocellular carcinoma

growth/size/body

enlarged liver ( J:162628 )

• slightly

Allelic Composition	Yap1^tm1.1Dupa/Yap1^tm1.1Dupa Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Speer6-ps1^{Tg(Alb-cre)21Mgn} mutation (6 available); any Speer6-ps1 mutation (4 available)
Yap1^tm1.1Dupa mutation (2 available); any Yap1 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

enlarged liver ( J:162628 )

liver/biliary system

increased hepatocyte apoptosis ( J:162628 )

• at 1 to 2 months

increased hepatocyte proliferation ( J:162628 )

abnormal bile duct morphology ( J:162628 )

• after 30 weeks, mice lack bile ducts or bile duct-like structures unlike wild-type mice

abnormal bile duct development ( J:162628 )

• livers fail to form mature bile ducts unlike in wild-type mice

enlarged liver ( J:162628 )

abnormal hepatocyte morphology ( J:162628 )

• at 1 to 2 months, the liver contains multiple areas of injured hepatocytes unlike in wild-type mice

macrovesicular hepatic steatosis ( J:162628 )

liver cirrhosis ( J:162628 )

liver fibrosis ( J:162628 )

• mice exhibit progressive liver fibrosis with early periportal fibrosis at 20 weeks unlike wild-type mice

• at 30 weeks, mice exhibit advanced fibrosis with cirrhosis unlike wild-type mice

pale liver ( J:162628 )

homeostasis/metabolism

increased circulating bilirubin level ( J:162628 )

increased circulating alanine transaminase level ( J:162628 )

endocrine/exocrine glands

abnormal bile duct morphology ( J:162628 )

• after 30 weeks, mice lack bile ducts or bile duct-like structures unlike wild-type mice

abnormal bile duct development ( J:162628 )

• livers fail to form mature bile ducts unlike in wild-type mice

cellular

increased hepatocyte apoptosis ( J:162628 )

• at 1 to 2 months

increased hepatocyte proliferation ( J:162628 )

Allelic Composition	Yap1^tm1.1Dupa/Yap1^tm1.1Dupa Tg(Vil1-cre)997Gum/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Vil1-cre)997Gum mutation (2 available)
Yap1^tm1.1Dupa mutation (2 available); any Yap1 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:165471 )

• in DSS-treated mice

digestive/alimentary system

digestive/alimentary phenotype ( J:165471 )

N	• mice, whether treated with DSS or not, do not develop colonic polyps

increased enterocyte apoptosis ( J:165471 )

• in DSS-treated mice

abnormal enterocyte proliferation ( J:165471 )

• DSS-treated mice exhibit decreased cell proliferation in the colon compared with similarly treated wild-type mice

increased susceptibility to induced colitis ( J:165471 )

• DSS-treated mice exhibit increased mortality a rapid decrease in body weight, increased apoptotic cells in the colon, and decreased proliferating cells in the colon compared with similarly treated wild-type mice

immune system

increased susceptibility to induced colitis ( J:165471 )

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:165471 )

• in DSS-treated mice

growth/size/body

increased susceptibility to weight loss ( J:165471 )

• in DSS-treated mice

cellular

increased enterocyte apoptosis ( J:165471 )

• in DSS-treated mice

abnormal enterocyte proliferation ( J:165471 )

• DSS-treated mice exhibit decreased cell proliferation in the colon compared with similarly treated wild-type mice

Allelic Composition	Sav1^tm1.1Dupa/Sav1^tm1.1Dupa Yap1^tm1.1Dupa/Yap1^tm1.1Dupa Tg(Vil1-cre)997Gum/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sav1^tm1.1Dupa mutation (1 available); any Sav1 mutation (20 available)
Tg(Vil1-cre)997Gum mutation (2 available)
Yap1^tm1.1Dupa mutation (2 available); any Yap1 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

digestive/alimentary phenotype ( J:165471 )

N	• mice exhibit normal cell proliferation in the small intestine and colon • mice, whether treated with DSS or not, do not develop colonic polyps

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