Phenotypes associated with this allele

• Allele Symbol: A830019P07Rik^{tm1a(KOMP)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4820036
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	A830019P07Rik^tm1a(KOMP)Wtsi/A830019P07Rik^tm1a(KOMP)Wtsi	C57BL/6N-A830019P07Rik^tm1a(KOMP)Wtsi	MGI:6458052

Genotype
MGI:6458052

hm1

• Allelic Composition: A830019P07Rik^{tm1a(KOMP)Wtsi}/A830019P07Rik^{tm1a(KOMP)Wtsi}
• Genetic Background: C57BL/6N-A830019P07Rik^{tm1a(KOMP)Wtsi}
• Cell Lines: EPD0614_5_B03

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:287356 )

N • at 3 and/or 4 months of age, males and female mice show normal body weight and blood glucose levels in the fed and fasted state relative to wild-type littermates

N • contrary to the 2-fold reduction in plasma insulin levels reported in non-fasting 16-week-old female and male mice by IKMC, mice of both sexes analyzed at 16 weeks of age in J:287356 show no differences in non-fasting and fasting plasma insulin levels relative to wild-type littermates

N • at 17 weeks of age, overnight fasted mice of both sexes show no alterations in glucose sensitivity or insulin response, as determined by an intra-peritoneal glucose tolerance test

N • pancreatic islets isolated from overnight fasted 3-month-old males show normal insulin release in response to glucose stimulation with no differences in islet insulin content or Ins2 mRNA levels relative to wild-type islets