All Phenotypes Tcte1<tm1a(KOMP)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tcte1^{tm1a(KOMP)Wtsi}
targeted mutation 1a, Wellcome Trust Sanger Institute
MGI:4820083

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tcte1^{tm1a(KOMP)Wtsi}/Tcte1^{tm1a(KOMP)Wtsi}	C57BL/6N-Tcte1^{tm1a(KOMP)Wtsi}	MGI:6111404
hm2	Tcte1^{tm1a(KOMP)Wtsi}/Tcte1^{tm1a(KOMP)Wtsi}	C57BL/6N-Tcte1^{tm1a(KOMP)Wtsi}/Wtsi	MGI:6263658

Allelic Composition	Tcte1^{tm1a(KOMP)Wtsi}/Tcte1^{tm1a(KOMP)Wtsi}
Genetic Background	C57BL/6N-Tcte1^{tm1a(KOMP)Wtsi}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcte1^{tm1a(KOMP)Wtsi} mutation (2 available); any Tcte1 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:243766 , J:243766 )

N	• female fertility (J:243766)
N	• testis weight (J:243766) • sperm number (J:243766) • spermatogenesis (J:243766) • acrosome morphology (J:243766) • tubules full of spermatozoa in caput epididymis (J:243766) • tubules full of spermatozoa in cauda epididymis (J:243766) • sperm axoneme morphology (J:243766)

abnormal gametes ( J:243766 )

• spermatozoa morphology

• significantly lower ATP levels in spermatozoa

abnormal sperm flagellum morphology ( J:243766 )

• limited flagellar beating range

• unbalanced flagellar beating

asthenozoospermia ( J:243766 )

• decreased forwardly motile spermatozoa using a Computer Assisted Sperm Analyzer (CASA)

male infertility ( J:243766 )

• no pups born from mating homozygous males to wildtype or heterozygous females

cellular

abnormal gametes ( J:243766 )

• spermatozoa morphology

• significantly lower ATP levels in spermatozoa

abnormal sperm flagellum morphology ( J:243766 )

• limited flagellar beating range

• unbalanced flagellar beating

asthenozoospermia ( J:243766 )

• decreased forwardly motile spermatozoa using a Computer Assisted Sperm Analyzer (CASA)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
male infertility		DOID:12336		J:243766

Allelic Composition	Tcte1^{tm1a(KOMP)Wtsi}/Tcte1^{tm1a(KOMP)Wtsi}
Genetic Background	C57BL/6N-Tcte1^{tm1a(KOMP)Wtsi}/Wtsi
Cell Lines	EPD0611_1_E08

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcte1^{tm1a(KOMP)Wtsi} mutation (2 available); any Tcte1 mutation (29 available)

Data Sources

IMPC Data for Tcte1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

male infertility ( J:211773 )

IMPC - WTSI

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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