Phenotypes associated with this allele

• Allele Symbol: Ace2^{tm1a(KOMP)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4820112
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ace2^tm1a(KOMP)Wtsi/Ace2^tm1a(KOMP)Wtsi Tg(FOXJ1-cre)F26Htzm/0	involves: C57BL/6N * C57BL/6NTac	MGI:6449146
cn2	Ace2^tm1a(KOMP)Wtsi/Y Tg(FOXJ1-cre)F26Htzm/0	involves: C57BL/6N * C57BL/6NTac	MGI:6449147

Genotype
MGI:6449146

cn1

• Allelic Composition: Ace2^{tm1a(KOMP)Wtsi}/Ace2^{tm1a(KOMP)Wtsi}; Tg(FOXJ1-cre)F26Htzm/0
• Genetic Background: involves: C57BL/6N * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:282139 )

♀ • mice infected with P. aeruginosa exhibit reduced survival rate

growth/size/body

increased susceptibility to weight loss ( J:282139 )

♀ • mice infected with P. aeruginosa exhibit a greater weight loss than controls

immune system

increased neutrophil cell number ( J:282139 )

♀ • mice infected with P. aeruginosa exhibit increased neutrophil infiltration in the lungs

lung inflammation ( J:282139 )

♀ • mice infected with P. aeruginosa exhibit exaggerated lung inflammation

increased susceptibility to bacterial infection ( J:282139 )

♀ • mice infected with P. aeruginosa exhibit weight loss, enhanced lung permeability, increased neutrophil infiltration into the lungs, reduced bacterial outgrowth in bronchoalveolar lavage fluid, and exaggerated lung inflammation and lung injury compared to controls

increased susceptibility to bacterial infection induced morbidity/mortality ( J:282139 )

♀ • mice infected with P. aeruginosa exhibit reduced survival rate

hematopoietic system

increased neutrophil cell number ( J:282139 )

♀ • mice infected with P. aeruginosa exhibit increased neutrophil infiltration in the lungs

respiratory system

lung inflammation ( J:282139 )

♀ • mice infected with P. aeruginosa exhibit exaggerated lung inflammation

Genotype
MGI:6449147

cn2

• Allelic Composition: Ace2^{tm1a(KOMP)Wtsi}/Y; Tg(FOXJ1-cre)F26Htzm/0
• Genetic Background: involves: C57BL/6N * C57BL/6NTac

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:282139 )

♂ • mice infected with P. aeruginosa exhibit reduced survival rate

growth/size/body

increased susceptibility to weight loss ( J:282139 )

♂ • mice infected with P. aeruginosa exhibit a greater weight loss than controls

immune system

increased neutrophil cell number ( J:282139 )

♂ • mice infected with P. aeruginosa exhibit increased neutrophil infiltration in the lungs

lung inflammation ( J:282139 )

♂ • mice infected with P. aeruginosa exhibit exaggerated lung inflammation

increased susceptibility to bacterial infection ( J:282139 )

♂ • mice infected with P. aeruginosa exhibit weight loss, enhanced lung permeability, increased neutrophil infiltration into the lungs, reduced bacterial outgrowth in bronchoalveolar lavage fluid, and exaggerated lung inflammation and lung injury compared to controls

increased susceptibility to bacterial infection induced morbidity/mortality ( J:282139 )

♂ • mice infected with P. aeruginosa exhibit reduced survival rate

hematopoietic system

increased neutrophil cell number ( J:282139 )

♂ • mice infected with P. aeruginosa exhibit increased neutrophil infiltration in the lungs

respiratory system

lung inflammation ( J:282139 )

♂ • mice infected with P. aeruginosa exhibit exaggerated lung inflammation