Phenotypes associated with this allele

• Allele Symbol: Clpp^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4820264
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Clpp^tm1a(EUCOMM)Wtsi/Clpp^tm1a(EUCOMM)Wtsi	C57BL/6N-Clpp^tm1a(EUCOMM)Wtsi/Wtsi	MGI:5700841

Genotype
MGI:5700841

hm1

• Allelic Composition: Clpp^{tm1a(EUCOMM)Wtsi}/Clpp^{tm1a(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Clpp^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0665_3_D05

Data Sources

IMPC Data for Clpp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased total body fat amount ( J:211773 )

♂

IMPC - WTSI

increased total body fat amount ( J:211773 )

IMPC - WTSI

behavior/neurological

tremors ( J:211773 )

♀

IMPC - WTSI

growth/size/body

decreased lean body mass ( J:211773 )

IMPC - WTSI

increased lean body mass ( J:211773 )

IMPC - WTSI

decreased body length ( J:211773 )

♀

IMPC - WTSI

hearing/vestibular/ear

abnormal auditory brainstem response ( J:211773 )

IMPC - WTSI

hematopoietic system

increased hematocrit ( J:211773 )

IMPC - WTSI

increased hemoglobin content ( J:211773 )

IMPC - WTSI

increased mean corpuscular hemoglobin ( J:211773 )

IMPC - WTSI

decreased red blood cell distribution width ( J:211773 )

IMPC - WTSI

thrombocytopenia ( J:211773 )

♂

IMPC - WTSI

decreased effector memory CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased NK T cell number ( J:211773 )

IMPC - WTSI

decreased memory-marker CD4-negative NK T cell number ( J:211773 )

IMPC - WTSI

decreased CD4-positive NK T cell number ( J:211773 )

IMPC - WTSI

decreased memory-marker CD4-positive NK T cell number ( J:211773 )

IMPC - WTSI

decreased gamma-delta T cell number ( J:211773 )

♀

IMPC - WTSI

increased leukocyte cell number ( J:211773 )

♀

IMPC - WTSI

increased B cell number ( J:211773 )

♀

IMPC - WTSI

increased mature B cell number ( J:211773 )

IMPC - WTSI

increased KLRG1-positive NK cell number ( J:211773 )

IMPC - WTSI

increased monocyte cell number ( J:211773 )

IMPC - WTSI

increased Ly6C high monocyte number ( J:211773 )

♀

IMPC - WTSI

increased Ly6C low monocyte number ( J:211773 )

♀

IMPC - WTSI

homeostasis/metabolism

increased circulating bilirubin level ( J:211773 )

IMPC - WTSI

decreased circulating fructosamine level ( J:211773 )

♀

IMPC - WTSI

decreased circulating glucose level ( J:211773 )

♂

IMPC - WTSI

increased circulating cholesterol level ( J:211773 )

IMPC - WTSI

increased circulating glycerol level ( J:211773 )

IMPC - WTSI

increased circulating iron level ( J:211773 )

♂

IMPC - WTSI

increased circulating alkaline phosphatase level ( J:211773 )

♂

IMPC - WTSI

increased circulating aspartate transaminase level ( J:211773 )

♂

IMPC - WTSI

increased circulating serum albumin level ( J:211773 )

♂

IMPC - WTSI

immune system

decreased effector memory CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased NK T cell number ( J:211773 )

IMPC - WTSI

decreased memory-marker CD4-negative NK T cell number ( J:211773 )

IMPC - WTSI

decreased CD4-positive NK T cell number ( J:211773 )

IMPC - WTSI

decreased memory-marker CD4-positive NK T cell number ( J:211773 )

IMPC - WTSI

decreased gamma-delta T cell number ( J:211773 )

♀

IMPC - WTSI

increased leukocyte cell number ( J:211773 )

♀

IMPC - WTSI

increased B cell number ( J:211773 )

♀

IMPC - WTSI

increased mature B cell number ( J:211773 )

IMPC - WTSI

increased KLRG1-positive NK cell number ( J:211773 )

IMPC - WTSI

increased monocyte cell number ( J:211773 )

IMPC - WTSI

increased Ly6C high monocyte number ( J:211773 )

♀

IMPC - WTSI

increased Ly6C low monocyte number ( J:211773 )

♀

IMPC - WTSI

reproductive system

female infertility ( J:211773 )

♀

IMPC - WTSI

male infertility ( J:211773 )

♂

IMPC - WTSI

skeleton

abnormal bone structure ( J:211773 )

♀

IMPC - WTSI

decreased bone mineral content ( J:211773 )

IMPC - WTSI

decreased bone mineral density ( J:211773 )

IMPC - WTSI