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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mapk1tm2Melo
targeted mutation 2, Sylvain Meloche
MGI:4820400
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Mapk1tm2Melo/Mapk1tm2Melo
Mapk3tm1Gpg/Mapk3tm1Gpg 		involves: 129 MGI:4820403


Genotype
MGI:4820403
cn1
Allelic
Composition		 Mapk1tm2Melo/Mapk1tm2Melo
Mapk3tm1Gpg/Mapk3tm1Gpg
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk1tm2Melo mutation (0 available); any Mapk1 mutation (43 available)
Mapk3tm1Gpg mutation (1 available); any Mapk3 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal mitosis ( J:162580 )
• more mouse embryonic fibroblasts (MEF) exposed to a cre-expressing retroviral vector are in G0/G1 phase and fewer in S phase than MEF not exposed to cre
increased fibroblast apoptosis ( J:162580 )
• in mouse embryonic fibroblasts exposed to a cre-expressing retroviral vector
early cellular replicative senescence ( J:162580 )
• mouse embryonic fibroblasts (MEFs) exposed to a cre-expressing retroviral vector exhibit increased senescence compared with MEFs not exposed to cre




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory