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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(ATP6V1B1-cre)45Rnel
transgene insertion 45, Raoul Nelson
MGI:4820423
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Itgb1tm1Efu/Itgb1tm1Efu
Tg(ATP6V1B1-cre)45Rnel/0 		involves: 129X1/SvJ * C57BL/6 MGI:4868737
cn2
 		Rhbgtm1.1Idw/Rhbgtm1.1Idw
Tg(ATP6V1B1-cre)45Rnel/0 		involves: C57BL/6 MGI:5477810
cn3
 		Dmbt1tm2Qaa/Dmbt1tm2Qaa
Tg(ATP6V1B1-cre)45Rnel/0 		involves: C57BL/6 * C57BL/6J * CBA MGI:4868736


Genotype
MGI:4868737
cn1
Allelic
Composition		 Itgb1tm1Efu/Itgb1tm1Efu
Tg(ATP6V1B1-cre)45Rnel/0
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb1tm1Efu mutation (2 available); any Itgb1 mutation (59 available)
Tg(ATP6V1B1-cre)45Rnel mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
metabolic acidosis ( J:167156 )
• metabolic acidosis

renal/urinary system
abnormal kidney cortex morphology ( J:167156 )
• in the kidney cortex, beta-intercalated cells are replaced with alpha-intercalated cells unlike in wild-type mice

hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:167156 )
N
• mice exhibit normal compound action potentials




Genotype
MGI:5477810
cn2
Allelic
Composition		 Rhbgtm1.1Idw/Rhbgtm1.1Idw
Tg(ATP6V1B1-cre)45Rnel/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhbgtm1.1Idw mutation (1 available); any Rhbg mutation (22 available)
Tg(ATP6V1B1-cre)45Rnel mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
homeostasis/metabolism phenotype ( J:195261 )
N
• no differences in titratable acid excretion, urine pH, urinary electrolyte excretion, serum bicarbonate levels, or serum potassium levels are detected under basal or acid loading conditions
decreased urine ammonia level ( J:195261 )
• following acid loading, urinary ammonia levels are reduced by about 25% compared to controls
• however, basal ammonia excretion is similar to controls

renal/urinary system
decreased urine ammonia level ( J:195261 )
• following acid loading, urinary ammonia levels are reduced by about 25% compared to controls
• however, basal ammonia excretion is similar to controls




Genotype
MGI:4868736
cn3
Allelic
Composition		 Dmbt1tm2Qaa/Dmbt1tm2Qaa
Tg(ATP6V1B1-cre)45Rnel/0
Genetic
Background		 involves: C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmbt1tm2Qaa mutation (0 available); any Dmbt1 mutation (111 available)
Tg(ATP6V1B1-cre)45Rnel mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
metabolic acidosis ( J:167156 )
• metabolic acidosis

renal/urinary system
abnormal kidney cortex morphology ( J:167156 )
• in the kidney cortex, beta-intercalated cells are replaced with alpha-intercalated cells unlike in wild-type mice

hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:167156 )
N
• mice exhibit normal compound action potentials




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Send questions and comments to User Support. 		last database update
09/17/2024
MGI 6.24 		The Jackson Laboratory