Analysis Tools
growth/size/body
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• exhibited accelerated body weight gain with more rapid body fat accumulation, developing marked adultonset obesity with >10% higher body fat mass after the age of 35 weeks for males and 30 weeks for females
• homozygous animals at younger ages were slightly leaner than their WT counterparts until reaching comparable body weight and adiposity levels at the age of around 15 weeks
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adipose tissue
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• exhibited accelerated body weight gain with more rapid body fat accumulation, developing marked adultonset obesity with >10% higher body fat mass after the age of 35 weeks for males and 30 weeks for females
• homozygous animals at younger ages were slightly leaner than their WT counterparts until reaching comparable body weight and adiposity levels at the age of around 15 weeks
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homeostasis/metabolism
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• male mice at the age of 39 weeks had moderately but significantly increased serum levels of glucose and insulin in the fasted state in comparison with WT littermates
• mutant mice fed the high-fat diet for 13 weeks displayed higher degrees of hyperleptinemia and hyperinsulinemia than their WT counterparts
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• In parallel with the age-dependent changes in their adiposity levels, male homozygous mice exhibited hyperleptinemia at the age of 39 weeks but displayed hypoleptinemia at 7 weeks in comparison with age-matched WT animals
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• in parallel with the age-dependent changes in their adiposity levels, male homozygous mice exhibited hyperleptinemia at the age of 39 weeks but displayed hypoleptinemia at 7 weeks in comparison with age-matched WT animals
• mutant mice fed the high-fat diet for 13 weeks displayed higher degrees of hyperleptinemia and hyperinsulinemia than their WT counterparts
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• In comparison with WT animals, male mutant mice, through a 12-hour light/dark cycle, showed markedly reduced oxygen consumption rates over the light and dark cycles at 48 weeks of age and, conversely, significantly higher oxygen consumption rates at 7 weeks of age.
• Female mice at 50 weeks of age also displayed significantly lower oxygen consumption rates as well as dramatically reduced activities, but they had comparable metabolic rates and physical activity at 7 weeks of age.
• mutant mice fed the high-fat diet for 9 weeks exhibited a significantly decreased metabolic rate and physical activity through the dark cycle relative to their WT littermates
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• In comparison to WT animals, repeated intraperitoneal injection of leptin resulted in significantly less body weight reduction in 40-week-old male mutant mice, paralleled by insignificant appetite suppression
• 7-week-old mutant animals exhibited appreciably greater body weight reductions with similar decreases in food intake upon leptin treatment
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behavior/neurological
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• both male and female homozygous mice at 48 weeks of age exhibited considerably increased food intake; whereas 8-week-old males consumed significantly less food
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• males at the age of 48 weeks exhibited a tendency of decreased activity, whereas at the age of 7 weeks they showed an 2-fold increase in physical activity through the dark cycle
• Female mice at 50 weeks of age also displayed significantly lower oxygen consumption rates as well as dramatically reduced activities, but they had comparable metabolic rates and physical activity at 7 weeks of age.
• mutant mice fed the high-fat diet for 9 weeks exhibited a significantly decreased metabolic rate and physical activity through the dark cycle relative to their WT littermates
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