Phenotypes associated with this allele

• Allele Symbol: Ptk2^tm2.1Guan
• Allele Name: targeted mutation 2.1, Jun-Lin Guan
• Allele ID: MGI:4820570
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptk2^tm2.1Guan/Ptk2^tm2.1Guan	involves: 129P2/OlaHsd * C57BL/6J * FVB/N	MGI:4820571
cn2	Ptk2^tm2.1Guan/Ptk2^tm1.1Guan Tg(Tek-cre)12Flv/0	involves: 129P2/OlaHsd * C3H * C57BL/6 * FVB/N	MGI:4820572

Genotype
MGI:4820571

hm1

• Allelic Composition: Ptk2^tm2.1Guan/Ptk2^tm2.1Guan
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:162690 )

• no live homozygous embryos beyond embryonic day 10.5

Genotype
MGI:4820572

cn2

• Allelic Composition: Ptk2^tm2.1Guan/Ptk2^tm1.1Guan; Tg(Tek-cre)12Flv/0
• Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * FVB/N

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:162690 )

• fewer mutant embryos are recovered than Mendelian ratios starting at embryonic day (E)14.5; none are alive at birth

• no perivascular hemorrhages, normal vessels containing nucleated red blood cells, normal vascularization in placenta at E13.5

cardiovascular system

abnormal blood vessel morphology ( J:162690 )

• decreased number of vessels in the brain, spinal cord and skin at E13.5

dilated vasculature ( J:162690 )

• dilated vessels in the brain, spinal cord and skin at E12.5

increased vascular permeability ( J:162690 )

• increased permeability after recombinant adenoviruses encoding Cre infection of endothelial cells in vitro

cellular

increased apoptosis ( J:162690 )

• a slight increase in apoptosis in the liver at E13.5