Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^tm1(Ntn4)Dyl
• Allele Name: targeted mutation 1, Dean Y Li
• Allele ID: MGI:4820644
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm1(Ntn4)Dyl/Gt(ROSA)26Sor^+ Tg(KRT14-cre)1Amc/0	involves: 129/Sv * C57BL/6 * CBA	MGI:4820720

Genotype
MGI:4820720

cn1

• Allelic Composition: Gt(ROSA)26Sor^tm1(Ntn4)Dyl/Gt(ROSA)26Sor⁺; Tg(KRT14-cre)1Amc/0
• Genetic Background: involves: 129/Sv * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal blood vessel morphology ( J:162807 )

• mice exhibit an increase in blood vessel density in the skin compared with wild-type mice

• hair follicles are surrounded by lymphatic or blood vessels unlike in wild-type mice

abnormal skin vasculature morphology ( J:162807 )

• mice exhibit an increase in lymphatic and blood vessel density in the skin compared with wild-type mice

abnormal tumor vascularization ( J:162807 )

• transplanted MCF-7 tumor cells exhibit increased lymphangiogenesis compared to when transplanted into wild-type mice

abnormal cardiovascular system physiology ( J:162807 )

• mice exhibit increased in vitro and in vivo lymphatic permeability associated with disorganized lymphatic cell-cell junctions compared to in wild-type mice

neoplasm

abnormal tumor vascularization ( J:162807 )

• transplanted MCF-7 tumor cells exhibit increased lymphangiogenesis compared to when transplanted into wild-type mice

increased metastatic potential ( J:162807 )

• mice exhibit increased metastasis of transplanted mammary cancer cell (line 66c14) compared with similarly treated wild-type mice

growth/size/body

decreased body size ( J:162807 )

immune system

abnormal lymphatic vessel morphology ( J:162807 )

• mice exhibit increased in vitro and in vivo lymphatic permeability associated with disorganized lymphatic cell-cell junctions compared to in wild-type mice

abnormal lymphangiogenesis ( J:162807 )

• mice transplanted with human breast carcinoma MCF-7 cells exhibit increased lymphangiogenesis compared with similarly treated wild-type mice

lymphatic vessel hyperplasia ( J:162807 )

• mice exhibit an increase in lymphatic vessel density in the skin compared with wild-type mice

• hair follicles are surrounded by lymphatic or blood vessels unlike in wild-type mice

integument

abnormal skin vasculature morphology ( J:162807 )

• mice exhibit an increase in lymphatic and blood vessel density in the skin compared with wild-type mice

abnormal coat appearance ( J:162807 )

• poorly developed

abnormal hair follicle morphology ( J:162807 )

• hair follicles are surrounded by lymphatic or blood vessels unlike in wild-type mice

reddish skin ( J:162807 )