Phenotypes associated with this allele

• Allele Symbol: Psmg1^tm1.1Smta
• Allele Name: targeted mutation 1.1, Shigeo Murata
• Allele ID: MGI:4820728
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Psmg1^tm1.1Smta/Psmg1^tm1.1Smta	B6.Cg-Psmg1^tm1.1Smta	MGI:4820734
cn2	Psmg1^tm1.1Smta/Psmg1^tm1.1Smta Speer6-ps1^Tg(Alb-cre)21Mgn/Speer6-ps1^+	involves: C57BL/6 * CBA * DBA	MGI:4820736
cn3	Psmg1^tm1.1Smta/Psmg1^tm1.1Smta Tg(Nes-cre)1Kln/0	involves: C57BL/6 * CBA * SJL	MGI:4820735

Genotype
MGI:4820734

hm1

• Allelic Composition: Psmg1^tm1.1Smta/Psmg1^tm1.1Smta
• Genetic Background: B6.Cg-Psmg1^tm1.1Smta

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:162790 )

• mice are healthy and fertile

Genotype
MGI:4820736

cn2

• Allelic Composition: Psmg1^tm1.1Smta/Psmg1^tm1.1Smta; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
• Genetic Background: involves: C57BL/6 * CBA * DBA

mortality/aging

mortality/aging ( J:162790 )

N • mortality is normal through 18 months

liver/biliary system

abnormal liver sinusoid morphology ( J:162790 )

• narrow sinusoids

abnormal hepatic cord morphology ( J:162790 )

• irregular hepatic cords

abnormal hepatocyte morphology ( J:162790 )

• mice exhibit enlarged hepatocytes with irregular hepatic cords and narrow sinusoids compared to in wild-type mice

• hepatocytes exhibit aberrant proliferation of the peroxisomes compared with wild-type cells

abnormal hepatocyte physiology ( J:162790 )

• hepatocytes undergo premature senescence compared with wild-type cells

cardiovascular system

abnormal liver sinusoid morphology ( J:162790 )

• narrow sinusoids

Genotype
MGI:4820735

cn3

• Allelic Composition: Psmg1^tm1.1Smta/Psmg1^tm1.1Smta; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: C57BL/6 * CBA * SJL

mortality/aging

postnatal lethality, complete penetrance ( J:162790 )

• mice die by P21

nervous system

decreased cerebellar granule cell precursor proliferation ( J:162790 )

abnormal cerebral hemisphere morphology ( J:162790 )

• as early as P3, cerebrum weight is decreased compared to in wild-type mice

• however, the formation of pyramidal cell and granular cell layers is normal

decreased dentate gyrus size ( J:162790 )

• reduced

small hippocampus ( J:162790 )

thin cerebral cortex ( J:162790 )

abnormal cerebellum morphology ( J:162790 )

• as early as P3, cerebellum weight is decreased compared to in wild-type mice

abnormal cerebellum development ( J:162790 )

• mice lack the normal three layers observed in wild-type mice

behavior/neurological

limb grasping ( J:162790 )

tremors ( J:162790 )

ataxia ( J:162790 )

growth/size/body

postnatal growth retardation ( J:162790 )

cellular

decreased cerebellar granule cell precursor proliferation ( J:162790 )