renal/urinary system
• chloride excretion is increased compared to in wild-type mice
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• potassium excretion is increased compared to in wild-type mice
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• mice exhibit increased urinary loss of sodium over time compared with wild-type mice
• however, sodium urine concentration is normal
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• magnesium excretion is increased compared to in wild-type mice
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vision/eye
• thickened Descemet membrane
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• the corneal endothelium is thickened with intracellular vacuolation compared to in wild-type mice
• sodium concentration is increased in the corneal endothelium compared to in wild-type mice
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• loses the typical cuboidal shape of cells at the basal membrane and of flat cells at the surface unlike in wild-type mice
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• sodium and chloride concentrations are increased in the corneal stroma compared to in wild-type mice
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• mice exhibit an accumulation of sodium chloride crystals in the cornea unlike in wild-type mice
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hearing/vestibular/ear
• contain numerous intracellular vacuolations and extracellular edemas
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• endocochlear potential and steady state potential are reduced compared to in wild-type mice
• however, potassium concentrations in the scala media is normal
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• at 3 weeks of age
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• as determined by brainstem auditory evoked potential
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homeostasis/metabolism
• chloride excretion is increased compared to in wild-type mice
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• potassium excretion is increased compared to in wild-type mice
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• mice exhibit increased urinary loss of sodium over time compared with wild-type mice
• however, sodium urine concentration is normal
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• magnesium excretion is increased compared to in wild-type mice
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skeleton
• contain numerous intracellular vacuolations and extracellular edemas
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