All Phenotypes Gt(ROSA)26Sor<tm1(CAG-Sox2,-EGFP)Blh> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gt(ROSA)26Sor^{tm1(CAG-Sox2,-EGFP)Blh}
targeted mutation 1, Brigid L Hogan
MGI:4820800

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^{tm1(CAG-Sox2,-EGFP)Blh}/Gt(ROSA)26Sor^{tm1(CAG-Sox2,-EGFP)Blh} Scgb1a1^{tm1(cre/ERT)Blh}/Scgb1a1⁺	involves: 129S6/SvEv * C57BL/6	MGI:4820809
cn2	Gt(ROSA)26Sor^{tm1(CAG-Sox2,-EGFP)Blh}/Gt(ROSA)26Sor⁺ Scgb1a1^{tm1(cre/ERT)Blh}/Scgb1a1⁺	involves: 129S6/SvEv * C57BL/6	MGI:4820811
cn3	Gt(ROSA)26Sor^{tm1(CAG-Sox2,-EGFP)Blh}/Gt(ROSA)26Sor⁺ Tg(Sftpc-cre)1Blh/0	involves: 129S/SvEv * C57BL/6 * DBA/2	MGI:4820810

Allelic Composition	Gt(ROSA)26Sor^{tm1(CAG-Sox2,-EGFP)Blh}/Gt(ROSA)26Sor^{tm1(CAG-Sox2,-EGFP)Blh} Scgb1a1^{tm1(cre/ERT)Blh}/Scgb1a1⁺
Genetic Background	involves: 129S6/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(CAG-Sox2,-EGFP)Blh} mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Scgb1a1^{tm1(cre/ERT)Blh} mutation (1 available); any Scgb1a1 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

increased lung adenocarcinoma incidence ( J:161806 )

• at 12 to 34 weeks of tamoxifen treatment, 50% of mice exhibit well-defined adenocarcinomas unlike wild-type control mice

bronchial epithelial hyperplasia ( J:161806 )

• after 6 weeks of tamoxifen treatment, mice exhibit bronchial epithelial hyperplasia unlike wild-type control mice

neoplasm

increased lung adenocarcinoma incidence ( J:161806 )

• at 12 to 34 weeks of tamoxifen treatment, 50% of mice exhibit well-defined adenocarcinomas unlike wild-type control mice

Allelic Composition	Gt(ROSA)26Sor^{tm1(CAG-Sox2,-EGFP)Blh}/Gt(ROSA)26Sor⁺ Scgb1a1^{tm1(cre/ERT)Blh}/Scgb1a1⁺
Genetic Background	involves: 129S6/SvEv * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

bronchial epithelial hyperplasia ( J:161806 )

• after 13 weeks of tamoxifen treatment, mice exhibit bronchial epithelial hyperplasia unlike wild-type control mice

• however, areas of hyperplasia do not progress to cancer after 18 weeks of tamoxifen treatment

neoplasm

neoplasm ( J:161806 )

N	• areas of hyperplasia do not progress to cancer after 18 weeks of tamoxifen treatment

Allelic Composition	Gt(ROSA)26Sor^{tm1(CAG-Sox2,-EGFP)Blh}/Gt(ROSA)26Sor⁺ Tg(Sftpc-cre)1Blh/0
Genetic Background	involves: 129S/SvEv * C57BL/6 * DBA/2

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:161806 )

• most mice are sacrificed within a few weeks of birth with respiratory distress

respiratory system

abnormal lung morphology ( J:161806 )

• in mice surviving to 15 weeks

increased lung adenocarcinoma incidence ( J:161806 )

• in mice surviving to 15 weeks

bronchiolar epithelial hyperplasia ( J:161806 )

• in mice surviving to 15 weeks

bronchial epithelial hyperplasia ( J:161806 )

• in mice surviving to 15 weeks

lung epithelium hyperplasia ( J:161806 )

• mice that survive to 15 weeks exhibit hyperplasia of the lung epithelium in the bronchi, bronchioles, and alveoli unlike wild-type mice

respiratory distress ( J:161806 )

• within a few weeks of birth

neoplasm

increased lung adenocarcinoma incidence ( J:161806 )

• in mice surviving to 15 weeks

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