All Phenotypes Gprasp1<tm1.1Jlw> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gprasp1^tm1.1Jlw
targeted mutation 1.1, Jennifer L Whistler
MGI:4820816

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gprasp1^tm1.1Jlw/Gprasp1^tm1.1Jlw	involves: C57BL/6	MGI:4820818

Allelic Composition	Gprasp1^tm1.1Jlw/Gprasp1^tm1.1Jlw
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gprasp1^tm1.1Jlw mutation (0 available); any Gprasp1 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired behavioral response to cocaine ( J:161807 )

• cocaine-treated mice exhibit reduced sensitization that develops more slowly than in wild-type mice

• cocaine-treated mice exhibit reduced locomotor activity 15 minutes post-injection on days 3, 4, and 5 compared with similarly treated wild-type mice

• cocaine-treated mice do not develop sensitization until day 4 and exhibit a blunted response compared with wild-type mice

• however, locomotor response to cocaine treatment is normal on day 1

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