Phenotypes associated with this allele

• Allele Symbol: Mtor^tm1.1Clyn
• Allele Name: targeted mutation 1.1, Christopher Lynch
• Allele ID: MGI:4820819
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mtor^tm1.1Clyn/Mtor^tm1.1Clyn	involves: BALB/c * C57BL/6J	MGI:4820824
ht2	Mtor^tm1.1Clyn/Mtor^+	involves: BALB/c * C57BL/6J	MGI:4820825

Genotype
MGI:4820824

hm1

• Allelic Composition: Mtor^tm1.1Clyn/Mtor^tm1.1Clyn
• Genetic Background: involves: BALB/c * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality ( J:162945 )

Genotype
MGI:4820825

ht2

• Allelic Composition: Mtor^tm1.1Clyn/Mtor⁺
• Genetic Background: involves: BALB/c * C57BL/6J

muscle

decreased skeletal muscle weight ( J:162945 )

• gastrocnemius weight is decreased compared to in wild-type mice

abnormal muscle physiology ( J:162945 )

• the gastrocnemius exhibit a decreased in the rate of basal protein synthesis compared with wild-type muscle

• leucine-stimulated muscle protein synthesis is suppressed by LPS treatment unlike in wild-type mice

homeostasis/metabolism

decreased circulating insulin-like growth factor I level ( J:162945 )

• in response to LPS

growth/size/body

decreased lean body mass ( J:162945 )

• small

adipose tissue

increased total body fat amount ( J:162945 )

• absolute and relative percentages of fat mass tends to increase compared to in wild-type mice