Phenotypes associated with this allele

• Allele Symbol: Tg(Igh-Mir29a,-Mir29b-1,-hrGFP)#Cro
• Allele Name: transgene insertion, Carlo M Croce
• Allele ID: MGI:4820820
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(Igh-Mir29a,-Mir29b-1,-hrGFP)#Cro/0 Tg(Igh-V186.2-TCL1A)3Cro/0	involves: C3H * C57BL/6 * FVB/N	MGI:4820822
tg2	Tg(Igh-Mir29a,-Mir29b-1,-hrGFP)#Cro/0	FVB/N-Tg(Igh-Mir29a,-Mir29b-1,-hrGFP)#Cro	MGI:4820821

Genotype
MGI:4820822

cx1

• Allelic Composition: Tg(Igh-Mir29a,-Mir29b-1,-hrGFP)#Cro/0; Tg(Igh-V186.2-TCL1A)3Cro/0
• Genetic Background: involves: C3H * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

spleen hyperplasia ( J:162077 )

• 3-fold increases in spleen weight compared to Tg(Igh-V186.2-TCL1A)3Cro mice alone

increased B-1a cell number ( J:162077 )

• increased number of CD5+ B cells in spleen

immune system

spleen hyperplasia ( J:162077 )

• 3-fold increases in spleen weight compared to Tg(Igh-V186.2-TCL1A)3Cro mice alone

increased B-1a cell number ( J:162077 )

• increased number of CD5+ B cells in spleen

neoplasm

increased chronic lymphocytic leukemia incidence ( J:162077 )

• a significant increased number of CD5+CD19+ and CD5+IgM+ B-cell populations compared with Tg(Igh-V186.2-TCL1A)3Cro mice alone

growth/size/body

spleen hyperplasia ( J:162077 )

• 3-fold increases in spleen weight compared to Tg(Igh-V186.2-TCL1A)3Cro mice alone

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chronic lymphocytic leukemia		DOID:1040	OMIM:109543 OMIM:151400 OMIM:609630 OMIM:612557 OMIM:612558 OMIM:612559	J:162077

Genotype
MGI:4820821

tg2

• Allelic Composition: Tg(Igh-Mir29a,-Mir29b-1,-hrGFP)#Cro/0
• Genetic Background: FVB/N-Tg(Igh-Mir29a,-Mir29b-1,-hrGFP)#Cro

hematopoietic system

abnormal lymphopoiesis ( J:162077 )

• exhibit an increased number of atypical lymphoid cells and numerous malignant lymphoid cells

increased B-1a cell number ( J:162077 )

• expanded CD5+ B-cell population in spleen, peripheral blood and bone marrow

abnormal spleen morphology ( J:162077 )

enlarged spleen ( J:162077 )

spleen hyperplasia ( J:162077 )

• distorted architecture with lymphoid follicles in disarray

abnormal B cell physiology ( J:162077 )

• mice show impaired immune response in production of anti-sheep RBC (SRBC) antibodies after injection of SRBC

increased B cell proliferation ( J:162077 )

• increased B220+, Ki67+ immunohistochemical staining

decreased IgG1 level ( J:162077 )

decreased IgG2a level ( J:162077 )

decreased IgG2b level ( J:162077 )

immune system

abnormal lymphopoiesis ( J:162077 )

• exhibit an increased number of atypical lymphoid cells and numerous malignant lymphoid cells

increased B-1a cell number ( J:162077 )

• expanded CD5+ B-cell population in spleen, peripheral blood and bone marrow

abnormal spleen morphology ( J:162077 )

enlarged spleen ( J:162077 )

spleen hyperplasia ( J:162077 )

• distorted architecture with lymphoid follicles in disarray

abnormal B cell physiology ( J:162077 )

• mice show impaired immune response in production of anti-sheep RBC (SRBC) antibodies after injection of SRBC

increased B cell proliferation ( J:162077 )

• increased B220+, Ki67+ immunohistochemical staining

decreased IgG1 level ( J:162077 )

decreased IgG2a level ( J:162077 )

decreased IgG2b level ( J:162077 )

neoplasm

increased chronic lymphocytic leukemia incidence ( J:162077 )

• 50% CD5+CD19+IgM+ B cells shows clonal rearrangements of the IgH gene in three of five cases analyzed

growth/size/body

enlarged spleen ( J:162077 )

spleen hyperplasia ( J:162077 )

• distorted architecture with lymphoid follicles in disarray

cellular

increased B cell proliferation ( J:162077 )

• increased B220+, Ki67+ immunohistochemical staining

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chronic lymphocytic leukemia		DOID:1040	OMIM:109543 OMIM:151400 OMIM:609630 OMIM:612557 OMIM:612558 OMIM:612559	J:162077