All Phenotypes Traf3ip2<adjm> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Traf3ip2^adjm
atopic dermatitis from Japanese mice
MGI:4820827

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Traf3ip2^adjm/Traf3ip2^adjm	A.KOR-Traf3ip2^adjm	MGI:4820831
hm2	Traf3ip2^adjm/Traf3ip2^adjm	AK.KOR-Traf3ip2^adjm	MGI:4820834
hm3	Traf3ip2^adjm/Traf3ip2^adjm	B6.KOR-Traf3ip2^adjm	MGI:4820832
hm4	Traf3ip2^adjm/Traf3ip2^adjm	C.KOR-Traf3ip2^adjm	MGI:4820833
hm5	Traf3ip2^adjm/Traf3ip2^adjm	KOR-Traf3ip2^adjm	MGI:4820830

Allelic Composition	Traf3ip2^adjm/Traf3ip2^adjm
Genetic Background	A.KOR-Traf3ip2^adjm

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Traf3ip2^adjm mutation (3 available); any Traf3ip2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased IgE level ( J:162859 )

dermatitis ( J:162859 )

• less severe than on the KOR strain

integument

dermatitis ( J:162859 )

• less severe than on the KOR strain

hematopoietic system

increased IgE level ( J:162859 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
atopic dermatitis		DOID:3310	OMIM:603165 OMIM:PS603165	J:162859

Allelic Composition	Traf3ip2^adjm/Traf3ip2^adjm
Genetic Background	AK.KOR-Traf3ip2^adjm

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Traf3ip2^adjm mutation (3 available); any Traf3ip2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased IgE level ( J:162859 )

dermatitis ( J:162859 )

• less severe than on the KOR strain

integument

dermatitis ( J:162859 )

• less severe than on the KOR strain

hematopoietic system

increased IgE level ( J:162859 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
atopic dermatitis		DOID:3310	OMIM:603165 OMIM:PS603165	J:162859

Allelic Composition	Traf3ip2^adjm/Traf3ip2^adjm
Genetic Background	B6.KOR-Traf3ip2^adjm

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Traf3ip2^adjm mutation (3 available); any Traf3ip2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased IgE level ( J:162859 )

dermatitis ( J:162859 )

• less severe than on the KOR, A/J, BALB/c or AKR/J strain

integument

dermatitis ( J:162859 )

• less severe than on the KOR, A/J, BALB/c or AKR/J strain

hematopoietic system

increased IgE level ( J:162859 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
atopic dermatitis		DOID:3310	OMIM:603165 OMIM:PS603165	J:162859

Allelic Composition	Traf3ip2^adjm/Traf3ip2^adjm
Genetic Background	C.KOR-Traf3ip2^adjm

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Traf3ip2^adjm mutation (3 available); any Traf3ip2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased IgE level ( J:162859 )

dermatitis ( J:162859 )

• less severe than on the KOR strain

integument

dermatitis ( J:162859 )

• less severe than on the KOR strain

hematopoietic system

increased IgE level ( J:162859 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
atopic dermatitis		DOID:3310	OMIM:603165 OMIM:PS603165	J:162859

Allelic Composition	Traf3ip2^adjm/Traf3ip2^adjm
Genetic Background	KOR-Traf3ip2^adjm

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Traf3ip2^adjm mutation (3 available); any Traf3ip2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:162859 )

immune system

increased IgE level ( J:162859 )

• elevated in all, however female mice displaying serum IgE levels two times higher than those of male mice until 10 wk of age

dermatitis ( J:162859 )

• apparent at 5 wk of age, and is localized mainly to the face, including the ears, becoming progressively more severe

reproductive system

female infertility ( J:162859 )

integument

dermatitis ( J:162859 )

• apparent at 5 wk of age, and is localized mainly to the face, including the ears, becoming progressively more severe

thick epidermis ( J:162859 )

increased pruritus ( J:162859 )

hematopoietic system

increased IgE level ( J:162859 )

• elevated in all, however female mice displaying serum IgE levels two times higher than those of male mice until 10 wk of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
atopic dermatitis		DOID:3310	OMIM:603165 OMIM:PS603165	J:162859

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