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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm2(Foxo1)Jnk
targeted mutation 2, Jun Nakae
MGI:4820847
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm2(Foxo1)Jnk/Gt(ROSA)26Sor+
Pdpk1tm1Maka/Pdpk1tm1Maka
Tg(CAG-cat,-lacZ)11Miya/0
Tg(Pomc1-cre)16Lowl/0 		involves: 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N MGI:4820872


Genotype
MGI:4820872
cn1
Allelic
Composition		 Gt(ROSA)26Sortm2(Foxo1)Jnk/Gt(ROSA)26Sor+
Pdpk1tm1Maka/Pdpk1tm1Maka
Tg(CAG-cat,-lacZ)11Miya/0
Tg(Pomc1-cre)16Lowl/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(Foxo1)Jnk mutation (0 available); any Gt(ROSA)26Sor mutation (994 available)
Pdpk1tm1Maka mutation (0 available); any Pdpk1 mutation (138 available)
Tg(CAG-cat,-lacZ)11Miya mutation (0 available)
Tg(Pomc1-cre)16Lowl mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
adipose tissue
increased total body fat amount ( J:162892 )
• female mice exhibit a tended towards increased adiposity compared with wild-type mice

behavior/neurological
increased food intake ( J:162892 )
• mice exhibit increased food intake compared with wild-type mice and Pdpk1tm1Maka/Pdpk1tm1Maka Tg(CAG-cat-lacZ)11Miya Tg(Pomc1-cre)16Lowl mice

growth/size/body
increased body weight ( J:162892 )
• at 16 weeks, mice are significantly heavier than Pdpk1tm1Maka/Pdpk1tm1Maka Tg(CAG-cat-lacZ)11Miya Tg(Pomc1-cre)16Lowl mice




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory