Phenotypes associated with this allele

• Allele Symbol: Tg(Ins1-Tag,-luc)1Gcr
• Allele Name: transgene insertion 1, Gerhard Christofori
• Allele ID: MGI:4821096
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Ins1-Tag,-luc)1Gcr/0	FVB/N-Tg(Ins1-Tag,-luc)1Gcr	MGI:4821097
tg2	Tg(Ins1-Tag,-luc)1Gcr/0	involves: C57BL/6 * FVB/N	MGI:4821098

Genotype
MGI:4821097

tg1

• Allelic Composition: Tg(Ins1-Tag,-luc)1Gcr/0
• Genetic Background: FVB/N-Tg(Ins1-Tag,-luc)1Gcr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:162648 )

• overall median survival is 20.7 weeks (males - 22 weeks, females - 19.4 weeks)

neoplasm

increased insulinoma incidence ( J:162648 )

• develop pancreatic beta cell tumors

• average tumor volumes at 18-20 weeks of age are about 99 mm cubed and 65 mm cubed for females and males respectively with no significant difference between the sexes

• by 21-22 weeks of age average tumor volume in females is less than that in males

endocrine/exocrine glands

increased insulinoma incidence ( J:162648 )

• develop pancreatic beta cell tumors

• average tumor volumes at 18-20 weeks of age are about 99 mm cubed and 65 mm cubed for females and males respectively with no significant difference between the sexes

• by 21-22 weeks of age average tumor volume in females is less than that in males

Genotype
MGI:4821098

tg2

• Allelic Composition: Tg(Ins1-Tag,-luc)1Gcr/0
• Genetic Background: involves: C57BL/6 * FVB/N

neoplasm

increased insulinoma incidence ( J:162648 )

• tumor development is the same as in a pure FVB/N background

endocrine/exocrine glands

increased insulinoma incidence ( J:162648 )

• tumor development is the same as in a pure FVB/N background