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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Wdr77tm2Zwan
targeted mutation 2, Zhengxin Wang
MGI:4821121
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Wdr77tm2Zwan/Wdr77tm2Zwan involves: C57BL/6J MGI:4821122
cn2
 		Wdr77tm2Zwan/Wdr77tm2Zwan
Tg(Pbsn-cre)20Fwan/0 		involves: C57BL/6J * FVB/NCrl MGI:4821123


Genotype
MGI:4821122
hm1
Allelic
Composition		 Wdr77tm2Zwan/Wdr77tm2Zwan
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wdr77tm2Zwan mutation (0 available); any Wdr77 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:162922 )
• viable and fertile with no gross abnormalities




Genotype
MGI:4821123
cn2
Allelic
Composition		 Wdr77tm2Zwan/Wdr77tm2Zwan
Tg(Pbsn-cre)20Fwan/0
Genetic
Background		 involves: C57BL/6J * FVB/NCrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Pbsn-cre)20Fwan mutation (1 available)
Wdr77tm2Zwan mutation (0 available); any Wdr77 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal prostate gland anterior lobe morphology ( J:162922 )
• at 2 months of age the anterior lobe contains small glands and fewer epithelial foldings
abnormal prostate gland development ( J:162922 )
• expression analysis indicates a defect in epithelial cell differentiation
abnormal prostate gland branching morphogenesis ( J:162922 )
• significant impairment in the development of branches and ductal tips in all 3 lobes
abnormal prostate gland dorsolateral lobe morphology ( J:162922 )
• at 2 months of age the dorsolateral lobe has a few glands and clusters of small ducts composed of a simple low columnar epithelium
• these ducts resemble immature prostate
abnormal prostate gland duct morphology ( J:162922 )
• in the dorsolateral and ventral lobes clusters of small ducts composed of a simple low columnar epithelium are present
• these ducts resemble immature prostate
decreased prostate gland duct number ( J:162922 )
• decrease in the number of branches and terminal duct tips in all 3 lobes
abnormal prostate gland epithelium morphology ( J:162922 )
• the luminal epithelial layer is composed of cuboidal basal like cells rather than columnar secretory cells
prostate gland epithelial hyperplasia ( J:162922 )
• multifocal hyperproliferative epithelial cells are observed in every prostate lobe
• despite the presence of hyperproliferative cells no prostate tumors are detected in mice up to 6 months of age
small prostate gland ( J:162922 )
• about half the size of control glands
abnormal prostate gland ventral lobe morphology ( J:162922 )
• similar in appearance to the dorsolateral lobe
abnormal prostate gland physiology ( J:162922 )
• decrease in the protein concentrations in prostate gland secretions from intact males

endocrine/exocrine glands
abnormal prostate gland anterior lobe morphology ( J:162922 )
• at 2 months of age the anterior lobe contains small glands and fewer epithelial foldings
abnormal prostate gland development ( J:162922 )
• expression analysis indicates a defect in epithelial cell differentiation
abnormal prostate gland branching morphogenesis ( J:162922 )
• significant impairment in the development of branches and ductal tips in all 3 lobes
abnormal prostate gland dorsolateral lobe morphology ( J:162922 )
• at 2 months of age the dorsolateral lobe has a few glands and clusters of small ducts composed of a simple low columnar epithelium
• these ducts resemble immature prostate
abnormal prostate gland duct morphology ( J:162922 )
• in the dorsolateral and ventral lobes clusters of small ducts composed of a simple low columnar epithelium are present
• these ducts resemble immature prostate
decreased prostate gland duct number ( J:162922 )
• decrease in the number of branches and terminal duct tips in all 3 lobes
abnormal prostate gland epithelium morphology ( J:162922 )
• the luminal epithelial layer is composed of cuboidal basal like cells rather than columnar secretory cells
prostate gland epithelial hyperplasia ( J:162922 )
• multifocal hyperproliferative epithelial cells are observed in every prostate lobe
• despite the presence of hyperproliferative cells no prostate tumors are detected in mice up to 6 months of age
small prostate gland ( J:162922 )
• about half the size of control glands
abnormal prostate gland ventral lobe morphology ( J:162922 )
• similar in appearance to the dorsolateral lobe
abnormal prostate gland physiology ( J:162922 )
• decrease in the protein concentrations in prostate gland secretions from intact males




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
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