Phenotypes associated with this allele

• Allele Symbol: Dll1^m1Mhda
• Allele Name: mutation 1, Martin Hrabe de Angelis
• Allele ID: MGI:4821259
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dll1^m1Mhda/Dll1^m1Mhda	C3HeB/FeJ-Dll1^m1Mhda	MGI:4821282
ht2	Dll1^m1Mhda/Dll1^+	C3HeB/FeJ-Dll1^m1Mhda	MGI:4821283

Genotype
MGI:4821282

hm1

• Allelic Composition: Dll1^m1Mhda/Dll1^m1Mhda
• Genetic Background: C3HeB/FeJ-Dll1^m1Mhda

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:150183 )

• only 32% of expected mice are alive after weaning

growth/size/body

decreased body weight ( J:150183 )

Genotype
MGI:4821283

ht2

• Allelic Composition: Dll1^m1Mhda/Dll1⁺
• Genetic Background: C3HeB/FeJ-Dll1^m1Mhda

mortality/aging

premature death ( J:150183 )

• most mice die or are sacrificed within the first months of life

cardiovascular system

decreased heart rate ( J:150183 )

• non-significant trend

increased mean systemic arterial blood pressure ( J:150183 )

♀ • in female mice

increased systemic arterial diastolic blood pressure ( J:150183 )

♀ • in female mice

increased systemic arterial systolic blood pressure ( J:150183 )

♀ • in female mice

homeostasis/metabolism

increased blood uric acid level ( J:150183 )

decreased circulating cholesterol level ( J:150183 )

♂ • in male mice

decreased circulating triglyceride level ( J:150183 )

♂ • in male mice

increased basal metabolism ( J:150183 )

growth/size/body

increased lean body mass ( J:150183 )

♀ • in female mice

decreased body weight ( J:150183 )

decreased body height ( J:150183 )

behavior/neurological

hyperactivity ( J:150183 )

♀ • in female mice

skeleton

decreased bone mineral content ( J:150183 )

• whole body bone mineral content is reduced compared to in wild-type mice

decreased bone mineral density ( J:150183 )

• whole body bone mineral density is reduced compared to in wild-type mice

adipose tissue

decreased total body fat amount ( J:150183 )

immune system

immune system phenotype ( J:150183 )

N • mice exhibit normal levels of CD19+ and CD4+ cells