All Phenotypes Cacng2<tm1.1Mwa> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cacng2^tm1.1Mwa
targeted mutation 1.1, Masahiko Watanabe
MGI:4821763

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cacng2^tm1.1Mwa/Cacng2^tm1.1Mwa	involves: C57BL/6 * C57BL/6N * CBA	MGI:4821783
cx2	Cacng2^tm1.1Mwa/Cacng2^tm1.1Mwa Cacng7^tm1.1Mwa/Cacng7^tm1.1Mwa	involves: C57BL/6 * C57BL/6N * CBA	MGI:4821785

Allelic Composition	Cacng2^tm1.1Mwa/Cacng2^tm1.1Mwa
Genetic Background	involves: C57BL/6 * C57BL/6N * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacng2^tm1.1Mwa mutation (0 available); any Cacng2 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:163029 )

• 73% of control mouse body weight at 8-10 weeks of age

behavior/neurological

head bobbing ( J:163029 )

• head lifting

abnormal locomotor coordination ( J:163029 )

ataxia ( J:163029 )

• ataxic gait

abnormal gait ( J:163029 )

• ataxic gait

nervous system

decreased excitatory postsynaptic current amplitude ( J:163029 )

• peak amplitude of climbing fiber EPSCs is reduced relative to controls

reduced AMPA-mediated synaptic currents ( J:163029 )

• AMPA receptor mediated currents are reduced

Allelic Composition	Cacng2^tm1.1Mwa/Cacng2^tm1.1Mwa Cacng7^tm1.1Mwa/Cacng7^tm1.1Mwa
Genetic Background	involves: C57BL/6 * C57BL/6N * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacng2^tm1.1Mwa mutation (0 available); any Cacng2 mutation (26 available)
Cacng7^tm1.1Mwa mutation (0 available); any Cacng7 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:163029 )

• 70% of control mouse body weight

behavior/neurological

abnormal locomotor coordination ( J:163029 )

ataxia ( J:163029 )

• ataxic gait more severe than in Cacng2^tm1Mwa single homozygotes

abnormal gait ( J:163029 )

• ataxic gait more severe than in Cacng2^tm1Mwa single homozygotes

• cannot walk straight

• frequent tumbling and rolling

nervous system

decreased excitatory postsynaptic current amplitude ( J:163029 )

• peak amplitude of climbing fiber EPSCs is further reduced relative to Cacng2^tm1Mwa mice

reduced AMPA-mediated synaptic currents ( J:163029 )

• AMPA receptor mediated currents are further reduced relative to Cacng2^tm1Mwa mice

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