Phenotypes associated with this allele

• Allele Symbol: Cacng7^tm1.1Mwa
• Allele Name: targeted mutation 1.1, Masahiko Watanabe
• Allele ID: MGI:4821765
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cacng7^tm1.1Mwa/Cacng7^tm1.1Mwa	involves: C57BL/6 * C57BL/6N * CBA	MGI:4821784
cx2	Cacng2^tm1.1Mwa/Cacng2^tm1.1Mwa Cacng7^tm1.1Mwa/Cacng7^tm1.1Mwa	involves: C57BL/6 * C57BL/6N * CBA	MGI:4821785

Genotype
MGI:4821784

hm1

• Allelic Composition: Cacng7^tm1.1Mwa/Cacng7^tm1.1Mwa
• Genetic Background: involves: C57BL/6 * C57BL/6N * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:163029 )

• indistinguishable from wild-type controls

Genotype
MGI:4821785

cx2

• Allelic Composition: Cacng2^tm1.1Mwa/Cacng2^tm1.1Mwa; Cacng7^tm1.1Mwa/Cacng7^tm1.1Mwa
• Genetic Background: involves: C57BL/6 * C57BL/6N * CBA

growth/size/body

decreased body weight ( J:163029 )

• 70% of control mouse body weight

behavior/neurological

abnormal locomotor coordination ( J:163029 )

ataxia ( J:163029 )

• ataxic gait more severe than in Cacng2^tm1Mwa single homozygotes

abnormal gait ( J:163029 )

• ataxic gait more severe than in Cacng2^tm1Mwa single homozygotes

• cannot walk straight

• frequent tumbling and rolling

nervous system

decreased excitatory postsynaptic current amplitude ( J:163029 )

• peak amplitude of climbing fiber EPSCs is further reduced relative to Cacng2^tm1Mwa mice

reduced AMPA-mediated synaptic currents ( J:163029 )

• AMPA receptor mediated currents are further reduced relative to Cacng2^tm1Mwa mice