mortality/aging
cardiovascular system
• each mutant mouse displayed an incomplete AVSD (an atrial septal defect of the primum type)
• Background Sensitivity: the phenotype is incompletely penetrant was lost after repeated outcrossing to FVB; however, the phenotype was re-established after a two-generation backcross to a C57BL/6-A/J chromosome 15 chromosome substitution strain (C57BL/6J-Chr15A/NaJ)
|
limbs/digits/tail
• observed on all limbs
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
atrial heart septal defect 1 | DOID:0110106 |
OMIM:108800 |
J:163196 |