Phenotypes associated with this allele

• Allele Symbol: Bicc1^jcpk-67Gso
• Allele Name: juvenile congenital polycystic kidney disease 67 Generoso
• Allele ID: MGI:4821847
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Bicc1^jcpk-67Gso/Bicc1^jcpk-67Gso T(2;10)67Gso/T(2;10)67Gso	involves: 101/Rl * C3H/Rl * C57BL10a/E * SEC/RlGso	MGI:4821954

Genotype
MGI:4821954

cx1

• Allelic Composition: Bicc1^jcpk-67Gso/Bicc1^jcpk-67Gso; T(2;10)67Gso/T(2;10)67Gso
• Genetic Background: involves: 101/Rl * C3H/Rl * C57BL10a/E * SEC/RlGso

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:75799 )

• many homozygotes die immediately after birth

• earliest onset in mice homozygous for this allele compared with mice homozygous for Bicc1^jcpk or Bicc1^jcpk-bpk

postnatal lethality, incomplete penetrance ( J:75799 )

• most of those that survive the first day of life die by 3-4 days of age

behavior/neurological

weakness ( J:75799 )

• homozytgotes are weaker than unaffected littermates at birth

endocrine/exocrine glands

abnormal biliary ductule morphology ( J:75799 )

• ducts are increased in number and dilated, extending into the hepatic lobes

abnormal interlobular bile duct morphology ( J:75799 )

• no normal interlobular ducts are seen

biliary cyst ( J:75799 )

• bile ducts are increased in number and dilated and no normal interlobular ducts are seen

• cysts are lined with a single layer of low columnar to cuboidal cells

growth/size/body

biliary cyst ( J:75799 )

• bile ducts are increased in number and dilated and no normal interlobular ducts are seen

• cysts are lined with a single layer of low columnar to cuboidal cells

decreased birth body size ( J:75799 )

• homozytgotes are smaller than unaffected littermates at birth

kidney cyst ( J:75799 )

• narrow elongated cysts extend radially from the cortex toward the medullary pyramid

• cortical collecting tubules are elongated, lined with cuboidal epithelium and dilated by cysts

• collecting tubules and glomeruli seem compressed by cysts

distended abdomen ( J:75799 )

• seen at 1-3 days of age

enlarged kidney ( J:75799 )

• bilateral enlargement

liver/biliary system

biliary cyst ( J:75799 )

• bile ducts are increased in number and dilated and no normal interlobular ducts are seen

• cysts are lined with a single layer of low columnar to cuboidal cells

abnormal liver morphology ( J:75799 )

• most extreme in mice homozygous for this allele compared with mice homozygous for Bicc1^jcpk or Bicc1^jcpk-bpk

abnormal biliary ductule morphology ( J:75799 )

• ducts are increased in number and dilated, extending into the hepatic lobes

abnormal liver parenchyma morphology ( J:75799 )

• normal parenchyma is lacking

abnormal interlobular bile duct morphology ( J:75799 )

• no normal interlobular ducts are seen

jaundice ( J:75799 )

• most homozygotes turn a yellow-orange color before death

renal/urinary system

abnormal kidney morphology ( J:75799 )

• pale and enlarged

kidney cyst ( J:75799 )

• narrow elongated cysts extend radially from the cortex toward the medullary pyramid

• cortical collecting tubules are elongated, lined with cuboidal epithelium and dilated by cysts

• collecting tubules and glomeruli seem compressed by cysts

enlarged kidney ( J:75799 )

• bilateral enlargement