All Phenotypes Cdh1<tm1.1Mpst> MGI Mouse

• die shortly after E11.5

• tetraploid complementation allows embryos to survive to at least E13

embryonic growth arrest ( J:163273 )

• at E10.5 embryos resemble E9.5 embryos

abnormal placenta morphology ( J:163273 )

• at E10.5 the overall size of the embryonic part of the placenta is reduced compared to heterozygous littermates

• mingling of embryonic and maternal blood vessels is reduced with embryonic red blood

• cells restricted to superficial layers rather than deeply penetrating into the labyrinth layer

• smaller compared to heterozygous littermates at E10.5

placental labyrinth hypoplasia ( J:163273 )

• expression analysis indicates a decrease in the number of cells in the labyrinth layer

• expression analysis indicates a decrease in the number of spongiotrophoblast layer cells

pale yolk sac ( J:163273 )

• at E10.5 - E11.5, the amount of blood in the yolk sac is reduced

abnormal placenta physiology ( J:163273 )

• at E10.5 cell cycle length is increased in cells in the placenta

• at E10.5 apoptosis is increased in the labyrinth layer and the chorionic plate

pallor ( J:163273 )

• at E10.5 - E11.5, the amount of blood in the embryonic tissues is reduced

• mingling of embryonic and maternal blood vessels is reduced with embryonic red blood

• cells restricted to superficial layers rather than deeply penetrating into the labyrinth layer

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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