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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tbx2tm2.2Vmc
targeted mutation 2.2, Vincent M Christoffels
MGI:4822020
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tbx2tm2.2Vmc/Tbx2tm2.2Vmc involves: 129S4/SvJaeSor * 129S7/SvEvBrd * FVB MGI:4822024


Genotype
MGI:4822024
hm1
Allelic
Composition		 Tbx2tm2.2Vmc/Tbx2tm2.2Vmc
Genetic
Background		 involves: 129S4/SvJaeSor * 129S7/SvEvBrd * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx2tm2.2Vmc mutation (0 available); any Tbx2 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Tbx2tm2.2Vmc/Tbx2tm2.2Vmc embryo shows duplication of digit IV on both hindlimbs

mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:163063 )
• no viable embryos are obtained after E13.5

limbs/digits/tail
postaxial polydactyly ( J:163063 )
• have a duplication of digit IV of both hind limbs

cardiovascular system
abnormal fetal atrioventricular canal morphology ( J:163063 )
• abnormal left atrioventricular canal tissue




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory